Literature DB >> 3202871

Age-related changes of heat shock protein gene transcription in human peripheral blood mononuclear cells.

Y Deguchi1, S Negoro, S Kishimoto.   

Abstract

In this study, we show the age-related retardation of heat shock 70 kD protein (hsp 70) gene transcription in peripheral blood mononuclear cells (PBMC). The amount of maximum transcription of the hsp 70 gene is decreased in PBMC from aged subjects, compared with PBMC from young control subjects. It might mean that the ability for homeostasis against heat shock stress decreases in PBMC from aged subjects. Our observation might be at least correlative and consistent with the age-related change of a possible essential function in PBMC.

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Year:  1988        PMID： 3202871     DOI： 10.1016/s0006-291x(88)80289-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  18 in total

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3.  Multifactorial Attenuation of the Murine Heat Shock Response With Age.

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4.  Spontaneous increase of transforming growth factor beta production by bronchoalveolar mononuclear cells of patients with systemic autoimmune diseases affecting the lung.

Authors:  Y Deguchi
Journal:  Ann Rheum Dis       Date:  1992-03       Impact factor: 19.103

Review 5.  Transcription factors and aging.

Authors:  A K Roy
Journal:  Mol Med       Date:  1997-08       Impact factor: 6.354

6.  Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with pulmonary sarcoidosis.

Authors:  Y Deguchi; S Kishimoto
Journal:  J Clin Pathol       Date:  1990-04       Impact factor: 3.411

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Authors:  Y Deguchi; S Kishimoto
Journal:  Ann Rheum Dis       Date:  1990-11       Impact factor: 19.103

8.  Stress-induced heat shock protein 70 expression in adrenal cortex: an adrenocorticotropic hormone-sensitive, age-dependent response.

Authors:  M J Blake; R Udelsman; G J Feulner; D D Norton; N J Holbrook
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

9.  Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone.

Authors:  Aaron J Przybysz; Keith P Choe; L Jackson Roberts; Kevin Strange
Journal:  Mech Ageing Dev       Date:  2009-03-13       Impact factor: 5.432

10.  Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.

Authors:  J Fargnoli; T Kunisada; A J Fornace; E L Schneider; N J Holbrook
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205
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