Literature DB >> 2300568

Decreased expression of heat shock protein 70 mRNA and protein after heat treatment in cells of aged rats.

J Fargnoli1, T Kunisada, A J Fornace, E L Schneider, N J Holbrook.   

Abstract

The effect of aging on the induction of heat shock protein 70 (HSP70)-encoding gene expression by elevated temperatures was studied in cultures of lung- or skin-derived fibroblasts from young (5 mo) and old (24 mo) male Wistar rats. Although the kinetics of the heat shock response were found to be similar in the two age groups, we observed lower levels of induction of HSP70 mRNA and HSP70 protein in confluent primary lung and skin fibroblast cultures derived from aged animals. Additional experiments with freshly excised lung tissue showed a similar age-related decline in the heat-induced expression of HSP70.

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Year:  1990        PMID： 2300568      PMCID： PMC53363          DOI： 10.1073/pnas.87.2.846

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

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Authors:  H Gershon; D Gershon
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3.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

4.  Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.

Authors:  D Finley; A Ciechanover; A Varshavsky
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5.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
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6.  Body temperature responses of aged mice to ambient temperature and humidity stress.

Authors:  L Hoffman-Goetz; R Keir
Journal:  J Gerontol       Date:  1984-09

7.  Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide.

Authors:  J W Cosgrove; I R Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1983-01       Impact factor: 11.205

8.  Synthesis of heat shock proteins in rat liver after ischemia and hyperthermia.

Authors:  G Cairo; L Bardella; L Schiaffonati; A Bernelli-Zazzera
Journal:  Hepatology       Date:  1985 May-Jun       Impact factor: 17.425

9.  Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

Authors:  G M Martin; C A Sprague; C J Epstein
Journal:  Lab Invest       Date:  1970-07       Impact factor: 5.662

10.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162
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  48 in total

1.  Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people.

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2.  Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population.

Authors:  Xingfang Jin; Ruibo Wang; Chengfeng Xiao; Longxian Cheng; Feng Wang; Li Yang; Taoyi Feng; Ming Chen; Sheng Chen; Xiaoye Fu; Jie Deng; Ru Wang; Fangfang Tang; Qingyi Wei; Robert M Tanguay; Tangchun Wu
Journal:  Cell Stress Chaperones       Date:  2004-03       Impact factor: 3.667

Review 3.  Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Authors:  Daniel W Neef; Alex M Jaeger; Dennis J Thiele
Journal:  Nat Rev Drug Discov       Date:  2011-12-01       Impact factor: 84.694

4.  Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.

Authors:  Rachel Raynes; Bruce D Leckey; Kevin Nguyen; Sandy D Westerheide
Journal:  J Biol Chem       Date:  2012-07-09       Impact factor: 5.157

5.  Heat shock transcription factor activation and hsp72 accumulation in aged skeletal muscle.

Authors:  M Locke
Journal:  Cell Stress Chaperones       Date:  2000-01       Impact factor: 3.667

6.  Expression profile of HSP genes during different seasons in goats (Capra hircus).

Authors:  Satyaveer Singh Dangi; Mahesh Gupta; Divakar Maurya; Vijay Prakash Yadav; Rudra Prasanna Panda; Gyanendra Singh; Nitai Haridas Mohan; Sanjeev Kumar Bhure; Bikash Chandra Das; Sadhan Bag; Ramkrishna Mahapatra; Guttalu Taru Sharma; Mihir Sarkar
Journal:  Trop Anim Health Prod       Date:  2012-04-26       Impact factor: 1.559

7.  Expression of heat shock protein 70 is altered by age and diet at the level of transcription.

Authors:  A R Heydari; B Wu; R Takahashi; R Strong; A Richardson
Journal:  Mol Cell Biol       Date:  1993-05       Impact factor: 4.272

8.  The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans.

Authors:  James F Morley; Heather R Brignull; Jill J Weyers; Richard I Morimoto
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-16       Impact factor: 11.205

9.  Induction of HSP70 gene expression by the antiproliferative prostaglandin PGA2: a growth-dependent response mediated by activation of heat shock transcription factor.

Authors:  N J Holbrook; S G Carlson; A M Choi; J Fargnoli
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10.  Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.

Authors:  James F Morley; Richard I Morimoto
Journal:  Mol Biol Cell       Date:  2003-12-10       Impact factor: 4.138
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