Literature DB >> 32019859

Double Trouble: Concomitant RB1 and BRCA2 Depletion Evokes Aggressive Phenotypes.

Amy C Mandigo1, Karen E Knudsen2,3,4,5,6.   

Abstract

Coordinate single- or two copy loss of the BRCA2/RB1 tumor suppressor genes, which reside in close chromosomal proximity, were found to be associated with aggressive prostate cancer and therapeutic resistance. Modeling these events and analyses of human cancers suggest that dual depletion of BRCA2/RB1 may represent a distinct subtype of disease.See related article by Chakraborty et al., p. 2047. ©2020 American Association for Cancer Research.

Entities:  

Year:  2020        PMID： 32019859      PMCID： PMC7165038          DOI： 10.1158/1078-0432.CCR-19-4033

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  12 in total

1.  The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression.

Authors:  Ankur Sharma; Wen-Shuz Yeow; Adam Ertel; Ilsa Coleman; Nigel Clegg; Chellappagounder Thangavel; Colm Morrissey; Xiaotun Zhang; Clay E S Comstock; Agnieszka K Witkiewicz; Leonard Gomella; Erik S Knudsen; Peter S Nelson; Karen E Knudsen
Journal:  J Clin Invest       Date:  2010-11-22       Impact factor: 14.808

2.  The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance.

Authors:  Himisha Beltran; Andrew Hruszkewycz; Howard I Scher; Jeffrey Hildesheim; Jennifer Isaacs; Evan Y Yu; Kathleen Kelly; Daniel Lin; Adam Dicker; Julia Arnold; Toby Hecht; Max Wicha; Rosalie Sears; David Rowley; Richard White; James L Gulley; John Lee; Maria Diaz Meco; Eric J Small; Michael Shen; Karen Knudsen; David W Goodrich; Tamara Lotan; Amina Zoubeidi; Charles L Sawyers; Charles M Rudin; Massimo Loda; Timothy Thompson; Mark A Rubin; Abdul Tawab-Amiri; William Dahut; Peter S Nelson
Journal:  Clin Cancer Res       Date:  2019-07-30       Impact factor: 12.531

3.  Integrative genomic profiling of human prostate cancer.

Authors:  Barry S Taylor; Nikolaus Schultz; Haley Hieronymus; Anuradha Gopalan; Yonghong Xiao; Brett S Carver; Vivek K Arora; Poorvi Kaushik; Ethan Cerami; Boris Reva; Yevgeniy Antipin; Nicholas Mitsiades; Thomas Landers; Igor Dolgalev; John E Major; Manda Wilson; Nicholas D Socci; Alex E Lash; Adriana Heguy; James A Eastham; Howard I Scher; Victor E Reuter; Peter T Scardino; Chris Sander; Charles L Sawyers; William L Gerald
Journal:  Cancer Cell       Date:  2010-06-24       Impact factor: 31.743

4.  Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.

Authors:  W K Cavenee; T P Dryja; R A Phillips; W F Benedict; R Godbout; B L Gallie; A L Murphree; L C Strong; R L White
Journal:  Nature       Date:  1983 Oct 27-Nov 2       Impact factor: 49.962

5.  Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types.

Authors:  William S Chen; Mohammed Alshalalfa; Paul L Nguyen; Felix Y Feng; Shuang G Zhao; Yang Liu; Brandon A Mahal; David A Quigley; Ting Wei; Elai Davicioni; Timothy R Rebbeck; Philip W Kantoff; Christopher A Maher; Karen E Knudsen; Eric J Small
Journal:  Clin Cancer Res       Date:  2019-04-22       Impact factor: 12.531

6.  Cell-Cycle Gene Alterations in 4,864 Tumors Analyzed by Next-Generation Sequencing: Implications for Targeted Therapeutics.

Authors:  Teresa Helsten; Shumei Kato; Maria Schwaederle; Brett N Tomson; Timon P H Buys; Sheryl K Elkin; Jennifer L Carter; Razelle Kurzrock
Journal:  Mol Cancer Ther       Date:  2016-05-11       Impact factor: 6.261

Review 7.  Molding BRCA2 function through its interacting partners.

Authors:  Juan S Martinez; Céline Baldeyron; Aura Carreira
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

8.  Significance of BRCA2 and RB1 Co-loss in Aggressive Prostate Cancer Progression.

Authors:  Goutam Chakraborty; Joshua Armenia; Ying Z Mazzu; Subhiksha Nandakumar; Konrad H Stopsack; Mohammad O Atiq; Kazumasa Komura; Lina Jehane; Rahim Hirani; Kalyani Chadalavada; Yuki Yoshikawa; Nabeela A Khan; Yu Chen; Wassim Abida; Lorelei A Mucci; Gwo-Shu Mary Lee; Gouri J Nanjangud; Philip W Kantoff
Journal:  Clin Cancer Res       Date:  2019-12-03       Impact factor: 12.531

Review 9.  Non-canonical functions of the RB protein in cancer.

Authors:  Frederick A Dick; David W Goodrich; Julien Sage; Nicholas J Dyson
Journal:  Nat Rev Cancer       Date:  2018-07       Impact factor: 60.716

10.  Integrative clinical genomics of metastatic cancer.

Authors:  Dan R Robinson; Yi-Mi Wu; Robert J Lonigro; Pankaj Vats; Erin Cobain; Jessica Everett; Xuhong Cao; Erica Rabban; Chandan Kumar-Sinha; Victoria Raymond; Scott Schuetze; Ajjai Alva; Javed Siddiqui; Rashmi Chugh; Francis Worden; Mark M Zalupski; Jeffrey Innis; Rajen J Mody; Scott A Tomlins; David Lucas; Laurence H Baker; Nithya Ramnath; Ann F Schott; Daniel F Hayes; Joseph Vijai; Kenneth Offit; Elena M Stoffel; J Scott Roberts; David C Smith; Lakshmi P Kunju; Moshe Talpaz; Marcin Cieślik; Arul M Chinnaiyan
Journal:  Nature       Date:  2017-08-02       Impact factor: 49.962
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  1 in total

1.  A first Japanese case of BRCA2 and RB1 co-loss organ-confined prostate cancer successfully treated by radical prostatectomy.

Authors:  Kazuhiro Matsumoto; Takeo Kosaka; Kohei Nakamura; Hiroshi Nishihara; Mototsugu Oya
Journal:  Int Cancer Conf J       Date:  2021-03-27
  1 in total

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