| Literature DB >> 20579941 |
Barry S Taylor1, Nikolaus Schultz, Haley Hieronymus, Anuradha Gopalan, Yonghong Xiao, Brett S Carver, Vivek K Arora, Poorvi Kaushik, Ethan Cerami, Boris Reva, Yevgeniy Antipin, Nicholas Mitsiades, Thomas Landers, Igor Dolgalev, John E Major, Manda Wilson, Nicholas D Socci, Alex E Lash, Adriana Heguy, James A Eastham, Howard I Scher, Victor E Reuter, Peter T Scardino, Chris Sander, Charles L Sawyers, William L Gerald.
Abstract
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource. Copyright (c) 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20579941 PMCID： PMC3198787 DOI： 10.1016/j.ccr.2010.05.026
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743