Literature DB >> 32016661

Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects.

Christian Schöneich1.   

Abstract

PURPOSE: Therapeutic proteins are sensitive to photo-degradation by UV A and visible light. As none of the essential amino acids exhibits significant absorption in the UV A and visible light regions, the underlying mechanisms of photo-degradation induced by UV A and visible light are not well understood. This review addresses potential mechanisms, by which protein structure, oxidative modifications or impurities can promote the photo-degradation of therapeutic proteins during the exposure to UV A and visible light.

Keywords:  histidine; photostability; protein oxidation; radicals; reaction mechanisms; tryptophan; tyrosine

Year:  2020        PMID： 32016661     DOI： 10.1007/s11095-020-2763-8

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  142 in total

1.  Direct spectroscopy of contact charge transfer states: possible consequences for tryptophan excited-state deactivation pathways by O2 and formation of reactive oxygen species.

Authors:  Swen Siegert; Ferdinand Vogeler; Joachim Schiedt; Rainer Weinkauf
Journal:  Phys Chem Chem Phys       Date:  2010-03-27       Impact factor: 3.676

2.  Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody.

Authors:  Amanda K Miller; David M Hambly; Bruce A Kerwin; Michael J Treuheit; Himanshu S Gadgil
Journal:  J Pharm Sci       Date:  2011-02-01       Impact factor: 3.534

3.  Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight.

Authors:  A Pirie
Journal:  Biochem J       Date:  1971-11       Impact factor: 3.857

4.  Gas chromatographic analysis of malonaldehyde and 4-hydroxy-2-(E)-nonenal produced from arachidonic acid and linoleic acid in a lipid peroxidation model system.

Authors:  H Tamura; T Shibamoto
Journal:  Lipids       Date:  1991-02       Impact factor: 1.880

5.  Oxidation of tyrosine photoinduced by pterin in aqueous solution.

Authors:  Carolina Castaño; María L Dántola; Esther Oliveros; Andrés H Thomas; Carolina Lorente
Journal:  Photochem Photobiol       Date:  2013-06-27       Impact factor: 3.421

6.  Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.

Authors:  R L Levine
Journal:  J Biol Chem       Date:  1983-10-10       Impact factor: 5.157

Review 7.  Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection.

Authors:  Georg T Wondrak; Myron K Jacobson; Elaine L Jacobson
Journal:  Photochem Photobiol Sci       Date:  2005-08-19       Impact factor: 3.982

8.  3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis.

Authors:  Anastasia Korlimbinis; Peter G Hains; Roger J W Truscott; J Andrew Aquilina
Journal:  Biochemistry       Date:  2006-02-14       Impact factor: 3.162

9.  Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway.

Authors:  Alavattam Sreedhara; Kimberly Lau; Charlene Li; Brian Hosken; Frank Macchi; Dejin Zhan; Amy Shen; Daniel Steinmann; Christian Schöneich; Yvonne Lentz
Journal:  Mol Pharm       Date:  2012-11-26       Impact factor: 4.939

10.  Simulated Sunlight Selectively Modifies Maillard Reaction Products in a Wide Array of Chemical Reactions.

Authors:  Daniel Hemmler; Michael Gonsior; Leanne C Powers; James W Marshall; Michael Rychlik; Andrew J Taylor; Philippe Schmitt-Kopplin
Journal:  Chemistry       Date:  2019-09-13       Impact factor: 5.236
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  3 in total

1.  Pharmaceutical Excipients Enhance Iron-Dependent Photo-Degradation in Pharmaceutical Buffers by near UV and Visible Light: Tyrosine Modification by Reactions of the Antioxidant Methionine in Citrate Buffer.

Authors:  Natalia Subelzu; Christian Schöneich
Journal:  Pharm Res       Date:  2021-04-21       Impact factor: 4.200

Review 2.  Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques.

Authors:  Elena Hipper; Michaela Blech; Dariush Hinderberger; Patrick Garidel; Wolfgang Kaiser
Journal:  Pharmaceutics       Date:  2021-12-28       Impact factor: 6.321

3.  Protein Concentrations in Stored Pooled Platelet Concentrates Treated with Pathogen Inactivation by Amotosalen Plus Ultraviolet a Illumination.

Authors:  Niels Arni Arnason; Freyr Johannsson; Ragna Landrö; Björn Hardarsson; Sveinn Gudmundsson; Aina-Mari Lian; Janne Reseland; Ottar Rolfsson; Olafur E Sigurjonsson
Journal:  Pathogens       Date:  2022-03-14
  3 in total

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