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Literature DB >> 5168391

Formation of N'-formylkynurenine in proteins from lens and other sources by exposure to sunlight.

Abstract

The photo-oxidative effect of sunlight on the tryptophan residues of proteins and on free tryptophan is described. Evidence is presented that the indole ring is split to yield N'-formylkynurenine. The possible relation of this photo-oxidative change to changes in the lens proteins of brown cataracts is discussed.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1971 PMID： 5168391 PMCID： PMC1178040 DOI： 10.1042/bj1250203

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

6 in total

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Authors: G G JAYSON; G SCHOLES; J WEISS
Journal: Biochem J Date: 1954-07 Impact factor: 3.857

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Authors: W E KNOX; A H MEHLER
Journal: J Biol Chem Date: 1950-11 Impact factor: 5.157

3. The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine.

Authors: A H MEHLER; W E KNOX
Journal: J Biol Chem Date: 1950-11 Impact factor: 5.157

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Authors: F G Lennox; R J Rowlands
Journal: Photochem Photobiol Date: 1969-04 Impact factor: 3.421

5. Studies on the structural proteins of the human lens.

Authors: R Clark; S Zigman; S Lerman
Journal: Exp Eye Res Date: 1969-04 Impact factor: 3.467

6. Non-enzymatic cleavage of tryptophyl peptide bonds in peptides and proteins. II. Release of a chemically modified tryptophan residue from model peptides by a mild basic treatment.

Authors: A Previero; M A Coletti-Previero; P Jollès
Journal: Biochim Biophys Acta Date: 1966-08-24

6 in total

24 in total

1. Electrospray mass and tandem mass spectrometry identification of ozone oxidation products of amino acids and small peptides.

Authors: T Kotiaho; M N Eberlin; P Vainiotalo; R Kostiainen
Journal: J Am Soc Mass Spectrom Date: 2000-06 Impact factor: 3.109

Review 2. Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists.

Authors: Shambhu D Varma; Svitlana Kovtun; Kavita R Hegde
Journal: Eye Contact Lens Date: 2011-07 Impact factor: 2.018

3. Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities.

Authors: Hangtian Song; Jianlin Xu; Mi Jin; Chao Huang; Jacob Bongers; He Bai; Wei Wu; Richard Ludwig; Zhengjian Li; Li Tao; Tapan K Das
Journal: Pharm Res Date: 2015-12-10 Impact factor: 4.200

4. Automated laser-scanning-microbeam fluorescence/Raman image analysis of human lens with multichannel detection: evidence for metabolic production of a green fluorophor.

Authors: N T Yu; M Z Cai; D J Ho; J F Kuck
Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205

Review 5. Photo-Degradation of Therapeutic Proteins: Mechanistic Aspects.

Authors: Christian Schöneich
Journal: Pharm Res Date: 2020-02-03 Impact factor: 4.200

Review 6. Determination of 8-methoxypsoralen in serum, aqueous, and lens: relation to long-wave ultraviolet phototoxicity in experimental and clinical photochemotherapy.

Authors: W B Glew
Journal: Trans Am Ophthalmol Soc Date: 1979

7. Lensfibre degeneration at cataract lenses. A LM, SEM and TEM investigation.

Authors: D Kalicharan; W L Jongebloed; J G Worst
Journal: Doc Ophthalmol Date: 1993 Impact factor: 2.379

8. Identification of tryptophan oxidation products in bovine alpha-crystallin.

Authors: E L Finley; J Dillon; R K Crouch; K L Schey
Journal: Protein Sci Date: 1998-11 Impact factor: 6.725

9. Probing folding and fluorescence quenching in human gammaD crystallin Greek key domains using triple tryptophan mutant proteins.

Authors: Melissa S Kosinski-Collins; Shannon L Flaugh; Jonathan King
Journal: Protein Sci Date: 2004-08 Impact factor: 6.725

10. Oxygen radical induced fluorescence in proteins; identification of the fluorescent tryptophan metabolite, N-formyl kynurenine, as a biological index of radical damage.

Authors: H R Griffiths; J Lunec; D R Blake
Journal: Amino Acids Date: 1992-06 Impact factor: 3.520