Literature DB >> 32010587

Advances in clinical trials of targeted therapy and immunotherapy of lung cancer in 2018.

Zhengyang Hu1, Ming Li1, Zhencong Chen1, Cheng Zhan1, Zongwu Lin1, Qun Wang1.   

Abstract

There were many clinical studies on lung cancer in 2018. In particular, significant progress has been made in immunotherapy and targeted therapy. Whether in small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC), immune checkpoint inhibitors (ICIs) have shown good results. For patients with specific gene mutations, the new generation inhibitors also showed good results in clinical trials. In this review, we summarize the clinical trials in lung cancer in 2018 and describe the progress and prospects for lung cancer therapies. 2019 Translational Lung Cancer Research. All rights reserved.

Entities:  

Keywords:  Non-small cell lung cancer (NSCLC); clinical trails; immunotherapy; small cell lung cancer (SCLC); targeted therapy

Year:  2019        PMID: 32010587      PMCID: PMC6976346          DOI: 10.21037/tlcr.2019.10.17

Source DB:  PubMed          Journal:  Transl Lung Cancer Res        ISSN: 2218-6751


  82 in total

Review 1.  Third generation triplet cytotoxic chemotherapy in advanced non-small cell lung cancer: a systematic overview.

Authors:  Hatem A Azim; Inas Elattar; Fausto R Loberiza; Hamdy Azim; Tony Mok; Apar Kishor Ganti
Journal:  Lung Cancer       Date:  2008-09-21       Impact factor: 5.705

2.  Ceritinib compassionate use for patients with crizotinib-refractory, anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer.

Authors:  Giulio Metro; Antonio Passaro; Giuseppe Lo Russo; Laura Bonanno; Raffaele Giusti; Vanesa Gregorc; Enrica Capelletto; Olga Martelli; Fabiana L Cecere; Diana Giannarelli; Andrea Luciani; Alessandra Bearz; Alessandro Tuzi; Vieri Scotti; Giuseppe Tonini; Domenico Galetta; Annamaria Carta; Hector Soto Parra; Alberto Rebonato; Alessandro Morabito; Rita Chiari
Journal:  Future Oncol       Date:  2017-11-14       Impact factor: 3.404

3.  Effect of Anlotinib as a Third-Line or Further Treatment on Overall Survival of Patients With Advanced Non-Small Cell Lung Cancer: The ALTER 0303 Phase 3 Randomized Clinical Trial.

Authors:  Baohui Han; Kai Li; Qiming Wang; Li Zhang; Jianhua Shi; Zhehai Wang; Ying Cheng; Jianxing He; Yuankai Shi; Yizhuo Zhao; Hao Yu; Yang Zhao; Weiqiang Chen; Yi Luo; Lin Wu; Xiuwen Wang; Robert Pirker; Kejun Nan; Faguang Jin; Jian Dong; Baolan Li; Yan Sun
Journal:  JAMA Oncol       Date:  2018-11-01       Impact factor: 31.777

4.  Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers.

Authors:  Helena A Yu; Maria E Arcila; Natasha Rekhtman; Camelia S Sima; Maureen F Zakowski; William Pao; Mark G Kris; Vincent A Miller; Marc Ladanyi; Gregory J Riely
Journal:  Clin Cancer Res       Date:  2013-03-07       Impact factor: 12.531

5.  Radiation-enhanced vascular targeting of human lung cancers in mice with a monoclonal antibody that binds anionic phospholipids.

Authors:  Jin He; Troy A Luster; Philip E Thorpe
Journal:  Clin Cancer Res       Date:  2007-09-01       Impact factor: 12.531

6.  Novel Mutations on EGFR Leu792 Potentially Correlate to Acquired Resistance to Osimertinib in Advanced NSCLC.

Authors:  Kai Chen; Fei Zhou; Wenxiang Shen; Tao Jiang; Xue Wu; Xiaoling Tong; Yang W Shao; Songbing Qin; Caicun Zhou
Journal:  J Thorac Oncol       Date:  2017-01-16       Impact factor: 15.609

7.  Erlotinib as single agent first line treatment in locally advanced or metastatic activating EGFR mutation-positive lung adenocarcinoma (CEETAC): an open-label, non-randomized, multicenter, phase IV clinical trial.

Authors:  Zsolt Markóczy; Veronika Sárosi; Iveta Kudaba; Gabriella Gálffy; Ülkü Yilmaz Turay; Ahmet Demirkazik; Gunta Purkalne; Attila Somfay; Zsolt Pápai-Székely; Erzsébet Rásó; Gyula Ostoros
Journal:  BMC Cancer       Date:  2018-05-25       Impact factor: 4.430

8.  Clinical activity of ASP8273 in Asian patients with non-small-cell lung cancer with EGFR activating and T790M mutations.

Authors:  Haruyasu Murakami; Hiroshi Nokihara; Hidetoshi Hayashi; Takashi Seto; Keunchil Park; Koichi Azuma; Chun-Ming Tsai; James Chih-Hsin Yang; Makoto Nishio; Sang-We Kim; Katsuyuki Kiura; Akira Inoue; Koji Takeda; Jin-Hyoung Kang; Tomoki Nakagawa; Kentaro Takeda; Rio Akazawa; Yuichiro Kaneko; Masashi Shimazaki; Satoshi Morita; Masahiro Fukuoka; Kazuhiko Nakagawa
Journal:  Cancer Sci       Date:  2018-08-09       Impact factor: 6.716

9.  Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC.

Authors:  Mark A Socinski; Robert M Jotte; Federico Cappuzzo; Francisco Orlandi; Daniil Stroyakovskiy; Naoyuki Nogami; Delvys Rodríguez-Abreu; Denis Moro-Sibilot; Christian A Thomas; Fabrice Barlesi; Gene Finley; Claudia Kelsch; Anthony Lee; Shelley Coleman; Yu Deng; Yijing Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Martin Reck
Journal:  N Engl J Med       Date:  2018-06-04       Impact factor: 91.245

10.  Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.

Authors:  Yong Jia; Cai-Hong Yun; Eunyoung Park; Dalia Ercan; Mari Manuia; Jose Juarez; Chunxiao Xu; Kevin Rhee; Ting Chen; Haikuo Zhang; Sangeetha Palakurthi; Jaebong Jang; Gerald Lelais; Michael DiDonato; Badry Bursulaya; Pierre-Yves Michellys; Robert Epple; Thomas H Marsilje; Matthew McNeill; Wenshuo Lu; Jennifer Harris; Steven Bender; Kwok-Kin Wong; Pasi A Jänne; Michael J Eck
Journal:  Nature       Date:  2016-05-25       Impact factor: 49.962

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  8 in total

1.  Efficacy and Safety of Anlotinib for Patients with Advanced NSCLC Who Progressed After Standard Regimens and the Preliminary Analysis of an Efficacy Predictor.

Authors:  Jian-De Cheng; Li-Xun Chai; Zhi-Ping Zhao; Yan-Yan Hao; Shuo Li
Journal:  Cancer Manag Res       Date:  2020-07-12       Impact factor: 3.989

Review 2.  Delayed cytokine release syndrome after neoadjuvant nivolumab: a case report and literature review.

Authors:  Aaron T Ciner; Howard S Hochster; David A August; Darren R Carpizo; Kristen R Spencer
Journal:  Immunotherapy       Date:  2021-07-21       Impact factor: 4.040

3.  Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2.

Authors:  Sha Huang; Tianyu He; Sijia Yang; Hongxu Sheng; Xiuwen Tang; Feichao Bao; Yiqing Wang; Xu Lin; Wenfeng Yu; Fei Cheng; Wang Lv; Jian Hu
Journal:  Transl Lung Cancer Res       Date:  2020-12

4.  The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels.

Authors:  Woo Hyun Park
Journal:  Molecules       Date:  2022-07-18       Impact factor: 4.927

5.  Tempol differently affects cellular redox changes and antioxidant enzymes in various lung-related cells.

Authors:  Woo Hyun Park
Journal:  Sci Rep       Date:  2021-07-21       Impact factor: 4.379

6.  Mouse lung automated segmentation tool for quantifying lung tumors after micro-computed tomography.

Authors:  Mary Katherine Montgomery; John David; Haikuo Zhang; Sripad Ram; Shibing Deng; Vidya Premkumar; Lisa Manzuk; Ziyue Karen Jiang; Anand Giddabasappa
Journal:  PLoS One       Date:  2021-06-17       Impact factor: 3.240

7.  Tissue MicroRNA Expression as a Predictor of Response to Immunotherapy in NSCLC Patients.

Authors:  Anna Grenda; Paweł Krawczyk; Justyna Błach; Izabela Chmielewska; Tomasz Kubiatowski; Stanisław Kieszko; Kamila Wojas-Krawczyk; Tomasz Kucharczyk; Bożena Jarosz; Iwona Paśnik; Małgorzata Borowiec-Bar; Małgorzata Frąk; Robert Kieszko; Michał Szczyrek; Katarzyna Reszka; Kinga Krukowska; Agnieszka Kolak; Sławomir Mańdziuk; Dariusz Kowalski; Marek Sawicki; Daria Świniuch; Elżbieta Starosławska; Rodryg Ramlau; Justyna Szumiło; Maciej Krzakowski; Janusz Milanowski
Journal:  Front Oncol       Date:  2021-02-08       Impact factor: 6.244

8.  Co-Occurring Potentially Actionable Oncogenic Drivers in Non-Small Cell Lung Cancer.

Authors:  Yiming Zhao; Shuyuan Wang; Zhengyu Yang; Yu Dong; Yanan Wang; Lele Zhang; Hai Hu; Baohui Han
Journal:  Front Oncol       Date:  2021-06-16       Impact factor: 6.244

  8 in total

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