Divya Mohan1, Victoria S Benson2, Matthew Allinder3, Nicholas Galwey4, Charlotte E Bolton5, John R Cockcroft6, William MacNee7, Ian B Wilkinson8, Ruth Tal-Singer1, Michael I Polkey9. 1. Medical Innovation, Value Evidence and Outcomes, GlaxoSmithKline, Collegeville, Pennsylvania. 2. Epidemiology, Value Evidence and Outcomes, GlaxoSmithKline, Middlesex, United Kingdom. 3. Quantitative Sciences and Statistics, GlaxoSmithKline, Collegeville, Pennsylvania. 4. Quantitative Sciences and Statistics, GlaxoSmithKline, Stevenage, United Kingdom. 5. National Institute for Health Research, Nottingham Biomedical Research Centre, Respiratory Theme and Department of Respiratory Medicine, University of Nottingham, School of Medicine, City Hospital, Nottingham University Hospitals National Health Service Trust Campus, Nottingham, United Kingdom. 6. Department of Cardiology, Wales Heart Research Institute, Cardiff University, Cardiff, United Kingdom. 7. Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom. 8. University of Cambridge, Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, Cambridge, United Kingdom. 9. National Institute for Health Research, Respiratory Biomedical Research Unit, Royal Brompton and Harefield National Health Service Foundation Trust and Imperial College, London, United Kingdom.
Abstract
OBJECTIVE: To identify phenotypic factors associated with the Short Physical Performance Battery (SPPB) and its individual sub-tests: standing balance, 4‑meter gait speed (4mGS) and 5-repetition sit-to-stand (5STS). METHODS: The Evaluation of the Role of Inflammation in non-pulmonary disease manifestations in Chronic Airways disease (ERICA) study recruited adult participants with stable chronic obstructive pulmonary disease (COPD). Proportional odds models identified factors associated with the SPPB, and a principal component analysis (PCA) evaluated how much SPPB variance was explainable by each of its 3 sub-tests. RESULTS: Of 729 enrolled participants, 717 (60% male, mean age 67 years) had full SPPB data. Overall, 76% of patients had some evidence of functional limitations (SPPB total score < 12). Scores < 4 were observed in 71%, 31%, and 22% of participants for the 5STS, 4mGS, and balance sub-tests, respectively. A longer 6-minute walk test and greater quadriceps maximal voluntary contraction decreased the odds of being in a lower score category for SPPB total score and for all 3 sub-tests. Aging, self-reported hypertension and higher dyspnea increased the odds, and being married decreased the odds of being in a lower category for total score. All sub-tests contributed equally to total score. CONCLUSION: Each of the 3 sub-tests contributed independent information to the SPPB, demonstrating their usefulness for assessing COPD when considered together rather than individually. The 5STS sub-test had the greatest variation in scores and may thus have the best discriminatory power for clinical COPD studies of lower limb performance where only one SPPB test is feasible. JCOPDF
OBJECTIVE: To identify phenotypic factors associated with the Short Physical Performance Battery (SPPB) and its individual sub-tests: standing balance, 4‑meter gait speed (4mGS) and 5-repetition sit-to-stand (5STS). METHODS: The Evaluation of the Role of Inflammation in non-pulmonary disease manifestations in Chronic Airways disease (ERICA) study recruited adult participants with stable chronic obstructive pulmonary disease (COPD). Proportional odds models identified factors associated with the SPPB, and a principal component analysis (PCA) evaluated how much SPPB variance was explainable by each of its 3 sub-tests. RESULTS: Of 729 enrolled participants, 717 (60% male, mean age 67 years) had full SPPB data. Overall, 76% of patients had some evidence of functional limitations (SPPB total score < 12). Scores < 4 were observed in 71%, 31%, and 22% of participants for the 5STS, 4mGS, and balance sub-tests, respectively. A longer 6-minute walk test and greater quadriceps maximal voluntary contraction decreased the odds of being in a lower score category for SPPB total score and for all 3 sub-tests. Aging, self-reported hypertension and higher dyspnea increased the odds, and being married decreased the odds of being in a lower category for total score. All sub-tests contributed equally to total score. CONCLUSION: Each of the 3 sub-tests contributed independent information to the SPPB, demonstrating their usefulness for assessing COPD when considered together rather than individually. The 5STS sub-test had the greatest variation in scores and may thus have the best discriminatory power for clinical COPD studies of lower limb performance where only one SPPB test is feasible. JCOPDF
Authors: J M Guralnik; L Ferrucci; C F Pieper; S G Leveille; K S Markides; G V Ostir; S Studenski; L F Berkman; R B Wallace Journal: J Gerontol A Biol Sci Med Sci Date: 2000-04 Impact factor: 6.053
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