Literature DB >> 3198115

Segregation of linked probes to myotonic dystrophy in a family demonstrating that 152 and APOC2 are on the same side of DM on 19q.

K Johnson1, E Nimmo, P Jones, M Weiss, M L Savontaus, M Anvret, R Bartlett, A Roses, D Shaw, P S Harper.   

Abstract

The two markers most closely linked to the myotonic dystrophy (DM) locus on chromosome 19 are the gene that codes for apolipoprotein CII (APOC2) and the anonymous probe D19S19 (LDR152). Both of these markers show tight linkage to DM, with maximum lod scores of greater than 20 at recombination fractions of less than 0.05. We have identified, in a family in which DM segregates, an affected individual where a meiotic recombination event has occurred in which both of these linked markers have crossed over with the gene defect. This demonstrates that APOC2 and D19S19 are probably on the same side of DM.

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Year:  1988        PMID： 3198115     DOI： 10.1007/bf00273655

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  15 in total

1.  Investigation of chromosome-mediated gene transfer using the HPRT region of the human X chromosome as a model.

Authors:  C A Pritchard; P N Goodfellow
Journal:  Genes Dev       Date:  1987-04       Impact factor: 11.361

2.  Confirmation of linkage of the loci for myotonic dystrophy and ABH secretion.

Authors:  J H Renwick; S E Bundey; M A Ferguson-Smith; M M Izatt
Journal:  J Med Genet       Date:  1971-12       Impact factor: 6.318

3.  A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands.

Authors:  X Estivill; M Farrall; P J Scambler; G M Bell; K M Hawley; N J Lench; G P Bates; H C Kruyer; P A Frederick; P Stanier
Journal:  Nature       Date:  1987 Apr 30-May 6       Impact factor: 49.962

4.  Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method.

Authors:  F S Collins; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

5.  The isolation and characterization of cDNA clones for human apolipoprotein CII.

Authors:  O Myklebost; B Williamson; A F Markham; S R Myklebost; J Rogers; D E Woods; S E Humphries
Journal:  J Biol Chem       Date:  1984-04-10       Impact factor: 5.157

6.  "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1984-02       Impact factor: 3.365

7.  RFLPs at the D19S19 locus of human chromosome 19 linked to myotonic dystrophy (DM).

Authors:  A D Roses; M A Pericak-Vance; D A Ross; L Yamaoka; R J Bartlett
Journal:  Nucleic Acids Res       Date:  1986-07-11       Impact factor: 16.971

8.  The gene for apolipoprotein C-II is closely linked to the gene for apolipo-protein E on chromosome 19.

Authors:  S E Humphries; K Berg; L Gill; A M Cumming; F W Robertson; A F Stalenhoef; R Williamson; A L Børresen
Journal:  Clin Genet       Date:  1984-11       Impact factor: 4.438

9.  The isolation of a genomic clone containing the apolipoprotein CII gene and the detection of linkage disequilibrium between two common DNA polymorphisms around the gene.

Authors:  S C Wallis; J A Donald; L A Forrest; R Williamson; S E Humphries
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

10.  Linkage analysis of myotonic dystrophy and sequences on chromosome 19 using a cloned complement 3 gene probe.

Authors:  K E Davies; J Jackson; R Williamson; P S Harper; S Ball; M Sarfarazi; L Meredith; G Fey
Journal:  J Med Genet       Date:  1983-08       Impact factor: 6.318
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  1 in total

1.  Linkage disequilibrium detected between dystrophia myotonica and APOC2 locus in the Finnish population.

Authors:  P Nokelainen; L Alanen-Kurki; R Winqvist; B Falck; H Somer; J Leisti; K Johnson; M L Savontaus; L Peltonen
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132
  1 in total

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