BACKGROUND: Turner syndrome (TS), a relatively rare chromosomal disease, is associated with multiple cardiovascular risk factors that possibly lead to increased left ventricular afterload and functional impairment. The aim of this study was to investigate whether alterations in myocardial work and work efficiency can be found in TS patients through left ventricular pressure-strain loop analysis (PSL). METHODS: Thirty-eight patients with TS and 19 healthy, age-matched controls were recruited for this study. Global peak systolic strain (GLPS) and PSL of the left ventricle was assessed in study participants. TS patients whose history included coarctation of the aorta or prior cardiac surgery were excluded from GLPS and PSL analyses (n=5). RESULTS: Median age was 16.00 years in the TS group and 16.35 years in the control group (P=0.236). GLPS did not show significant differences between both groups (P=0.524). TS patients demonstrated, compared to controls, a significantly higher global myocardial work index (BSA) (mean ± SD: 1,497±505 vs. 1,214±245 mmHg*%/m2; P=0.027). Heart rate was significantly increased in TS patients, compared to controls (mean ± SD: 90.08±14.79 vs. 73.95±15.05 bpm; P<0.001), and correlated significantly with global myocardial work index [body surface area (BSA)] within the TS cohort (r=0.558, P=0.001). CONCLUSIONS: TS patients showed signs of increased myocardial workload that were only detectable through the novel PSL analysis method and not through GLPS. Moreover, elevated resting heart rate was linked with increased myocardial workload in TS patients. Further studies will have to investigate whether TS patients may develop advanced left ventricular systolic dysfunction later in life. 2020 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: Turner syndrome (TS), a relatively rare chromosomal disease, is associated with multiple cardiovascular risk factors that possibly lead to increased left ventricular afterload and functional impairment. The aim of this study was to investigate whether alterations in myocardial work and work efficiency can be found in TS patients through left ventricular pressure-strain loop analysis (PSL). METHODS: Thirty-eight patients with TS and 19 healthy, age-matched controls were recruited for this study. Global peak systolic strain (GLPS) and PSL of the left ventricle was assessed in study participants. TS patients whose history included coarctation of the aorta or prior cardiac surgery were excluded from GLPS and PSL analyses (n=5). RESULTS: Median age was 16.00 years in the TS group and 16.35 years in the control group (P=0.236). GLPS did not show significant differences between both groups (P=0.524). TS patients demonstrated, compared to controls, a significantly higher global myocardial work index (BSA) (mean ± SD: 1,497±505 vs. 1,214±245 mmHg*%/m2; P=0.027). Heart rate was significantly increased in TS patients, compared to controls (mean ± SD: 90.08±14.79 vs. 73.95±15.05 bpm; P<0.001), and correlated significantly with global myocardial work index [body surface area (BSA)] within the TS cohort (r=0.558, P=0.001). CONCLUSIONS: TS patients showed signs of increased myocardial workload that were only detectable through the novel PSL analysis method and not through GLPS. Moreover, elevated resting heart rate was linked with increased myocardial workload in TS patients. Further studies will have to investigate whether TS patients may develop advanced left ventricular systolic dysfunction later in life. 2020 Quantitative Imaging in Medicine and Surgery. All rights reserved.
Authors: N H Andersen; B E Hjerrild; K Sørensen; E M Pedersen; K Stochholm; L C Gormsen; A Hørlyck; J S Christiansen; C H Gravholt Journal: Heart Date: 2006-10 Impact factor: 5.994
Authors: Anita T Cote; Aaron A Phillips; Kevin C Harris; George G S Sandor; Constadina Panagiotopoulos; Angela M Devlin Journal: Arterioscler Thromb Vasc Biol Date: 2015-01-29 Impact factor: 8.311
Authors: Anders Opdahl; Bharath Ambale Venkatesh; Veronica R S Fernandes; Colin O Wu; Khurram Nasir; Eui-Young Choi; Andre L C Almeida; Boaz Rosen; Benilton Carvalho; Thor Edvardsen; David A Bluemke; João A C Lima Journal: J Am Coll Cardiol Date: 2014-01-08 Impact factor: 24.094
Authors: Carolyn A Bondy; Phillip L Van; Vladimir K Bakalov; Vandana Sachdev; Carol A Malone; Vincent B Ho; Douglas R Rosing Journal: Medicine (Baltimore) Date: 2006-03 Impact factor: 1.889
Authors: Claus H Gravholt; Niels H Andersen; Gerard S Conway; Olaf M Dekkers; Mitchell E Geffner; Karen O Klein; Angela E Lin; Nelly Mauras; Charmian A Quigley; Karen Rubin; David E Sandberg; Theo C J Sas; Michael Silberbach; Viveca Söderström-Anttila; Kirstine Stochholm; Janielle A van Alfen-van derVelden; Joachim Woelfle; Philippe F Backeljauw Journal: Eur J Endocrinol Date: 2017-09 Impact factor: 6.664
Authors: Felix Sebastian Oberhoffer; Hashim Abdul-Khaliq; Mohamed Abd El Rahman; Anna-Maria Jung; Michael Zemlin; Tilman R Rohrer; Rita Schuck Journal: Quant Imaging Med Surg Date: 2022-05
Authors: Jolanda Sabatino; Isabella Leo; Antonio Strangio; Sabrina La Bella; Nunzia Borrelli; Martina Avesani; Manjit Josen; Josefa Paredes; Enrico Piccinelli; Domenico Sirico; Valeria Pergola; Alain Fraisse; Salvatore De Rosa; Ciro Indolfi; Giovanni Di Salvo Journal: Front Cardiovasc Med Date: 2022-04-25
Authors: Masood Abu-Halima; Felix Sebastian Oberhoffer; Viktoria Wagner; Mohamed Abd El Rahman; Anna-Maria Jung; Michael Zemlin; Tilman R Rohrer; Eckart Meese; Hashim Abdul-Khaliq Journal: Children (Basel) Date: 2022-07-23
Authors: Thuy T M Pham; Vien T Truong; Phuc N Vu; Truong X Tran; Nam N H Nguyen; Linh P T Nguyen; Hien N T Tu; Cassady Palmer; Justin T Tretter; Philip Levy; Wojciech Mazur; Vinh N Pham Journal: Pediatr Cardiol Date: 2021-07-30 Impact factor: 1.655
Authors: Iris D Noordman; Zina Fejzic; Melanie Bos; Anthonie L Duijnhouwer; Gert Weijers; Marlies Kempers; Remy Merkx; Janiëlle A E M van der Velden; Livia Kapusta Journal: Am J Med Genet A Date: 2021-05-10 Impact factor: 2.802