| Literature DB >> 31935372 |
Douglas Hanniford1, Alejandro Ulloa-Morales2, Alcida Karz2, Maria Gabriela Berzoti-Coelho3, Rana S Moubarak2, Beatriz Sánchez-Sendra4, Andreas Kloetgen2, Veronica Davalos5, Jochen Imig2, Pamela Wu6, Varshini Vasudevaraja7, Diana Argibay2, Karin Lilja8, Tommaso Tabaglio9, Carlos Monteagudo10, Ernesto Guccione11, Aristotelis Tsirigos12, Iman Osman13, Iannis Aifantis2, Eva Hernando14.
Abstract
Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield promising therapeutic insights. Here, we investigated the role of circular RNAs (circRNA) in metastasis, using melanoma as a model aggressive tumor. We identified silencing of cerebellar degeneration-related 1 antisense (CDR1as), a regulator of miR-7, as a hallmark of melanoma progression. CDR1as depletion results from epigenetic silencing of LINC00632, its originating long non-coding RNA (lncRNA) and promotes invasion in vitro and metastasis in vivo through a miR-7-independent, IGF2BP3-mediated mechanism. Moreover, CDR1as levels reflect cellular states associated with distinct therapeutic responses. Our study reveals functional, prognostic, and predictive roles for CDR1as and expose circRNAs as key players in metastasis.Entities:
Keywords: CDR1as; EZH2; GPX4; IGF2BP; LINC00632; PRC2; circRNA; melanoma; metastasis; miR-7
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Year: 2020 PMID： 31935372 PMCID： PMC7184928 DOI： 10.1016/j.ccell.2019.12.007
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743