| Literature DB >> 34385309 |
Xiaolin Wang1,2,3,4, Jingxin Li2, Xing Bian1,2,3,4, Cheng Wu5, Jinghan Hua1,2,3,4, Shuhui Chang2, Tianyi Yu2, Hong Li1,3,4, Yongxiang Li5, Shanshan Hu6, Ge Shan7, Wenchu Lin8,3,4.
Abstract
Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding nontumor adjacent specimens (paraGC). CircURI1 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, circURI1 directly interacts with heterogeneous nuclear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Collectively, our study expands the current knowledge regarding the molecular mechanism of circRNA-mediated cancer metastasis via modulating alternative splicing.Entities:
Keywords: alternative splicing; circURI1; gastric cancer; hnRNPM; metastasis
Mesh：
Substances：
Year: 2021 PMID： 34385309 PMCID： PMC8379983 DOI： 10.1073/pnas.2012881118
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205