Yun Bian1, Hui Jiang2, Chao Ma1, Kai Cao1, Xu Fang1, Jing Li1, Li Wang1, Jianming Zheng2, Jianping Lu3. 1. Department of Radiology, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China. 2. Department of Pathology, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China. 3. Department of Radiology, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China. cjr.lujianping@vip.163.com.
Abstract
OBJECTIVES: To accurately identify the relationship between a portal radiomics score (rad-score) and pathologic superior mesenteric vein (SMV) resection margin and to evaluate the diagnostic performance in patients with pancreatic head cancer. MATERIALS AND METHODS: A total of 181 patients with postoperatively and pathologically confirmed pancreatic head cancer who underwent multislice computed tomography within one month of resection between January 2016 and December 2018 were retrospectively investigated. For each patient, 1029 radiomics features of the portal phase were extracted, which were reduced using the least absolute shrinkage and selection operator (LASSO) logistic regression algorithm. Multivariate logistic regression models were used to analyze the association between the portal rad-score and SMV resection margin. RESULTS: Patients with negative (R0) and positive (R1) margins accounted for 70.17% (127) and 29.83% (54) of the cohort, respectively. The rad-score was significantly associated with the SMV resection margin status (p < 0.05). Multivariate analyses confirmed a significant and independent association between the portal rad-score and SMV resection margin (OR 4.62; 95% CI 2.19-9.76; p < 0.0001). The portal rad-score had high accuracy (area under the curve = 0.750). The best cut point based on maximizing the sum of sensitivity and specificity was - 0.741 (sensitivity = 64.8%; specificity = 74.0%; accuracy = 71.3%). Decision curve analysis indicated the clinical usefulness of radiomics score. CONCLUSIONS: The portal rad-score is significantly associated with the pathologic SMV resection margin, and it can accurately and noninvasively predict the SMV resection margin in patients with pancreatic cancer.
OBJECTIVES: To accurately identify the relationship between a portal radiomics score (rad-score) and pathologic superior mesenteric vein (SMV) resection margin and to evaluate the diagnostic performance in patients with pancreatic head cancer. MATERIALS AND METHODS: A total of 181 patients with postoperatively and pathologically confirmed pancreatic head cancer who underwent multislice computed tomography within one month of resection between January 2016 and December 2018 were retrospectively investigated. For each patient, 1029 radiomics features of the portal phase were extracted, which were reduced using the least absolute shrinkage and selection operator (LASSO) logistic regression algorithm. Multivariate logistic regression models were used to analyze the association between the portal rad-score and SMV resection margin. RESULTS:Patients with negative (R0) and positive (R1) margins accounted for 70.17% (127) and 29.83% (54) of the cohort, respectively. The rad-score was significantly associated with the SMV resection margin status (p < 0.05). Multivariate analyses confirmed a significant and independent association between the portal rad-score and SMV resection margin (OR 4.62; 95% CI 2.19-9.76; p < 0.0001). The portal rad-score had high accuracy (area under the curve = 0.750). The best cut point based on maximizing the sum of sensitivity and specificity was - 0.741 (sensitivity = 64.8%; specificity = 74.0%; accuracy = 71.3%). Decision curve analysis indicated the clinical usefulness of radiomics score. CONCLUSIONS: The portal rad-score is significantly associated with the pathologic SMV resection margin, and it can accurately and noninvasively predict the SMV resection margin in patients with pancreatic cancer.
Authors: Virendra Kumar; Yuhua Gu; Satrajit Basu; Anders Berglund; Steven A Eschrich; Matthew B Schabath; Kenneth Forster; Hugo J W L Aerts; Andre Dekker; David Fenstermacher; Dmitry B Goldgof; Lawrence O Hall; Philippe Lambin; Yoganand Balagurunathan; Robert A Gatenby; Robert J Gillies Journal: Magn Reson Imaging Date: 2012-08-13 Impact factor: 2.546
Authors: Marlo Blazer; Christina Wu; Richard M Goldberg; Gary Phillips; Carl Schmidt; Peter Muscarella; Evan Wuthrick; Terrence M Williams; Joshua Reardon; E Christopher Ellison; Mark Bloomston; Tanios Bekaii-Saab Journal: Ann Surg Oncol Date: 2014-10-31 Impact factor: 5.344
Authors: Bettina M Rau; Katharina Moritz; Sarah Schuschan; Guido Alsfasser; Friedrich Prall; Ernst Klar Journal: Surgery Date: 2012-07-03 Impact factor: 3.982
Authors: Philippe Lambin; Emmanuel Rios-Velazquez; Ralph Leijenaar; Sara Carvalho; Ruud G P M van Stiphout; Patrick Granton; Catharina M L Zegers; Robert Gillies; Ronald Boellard; André Dekker; Hugo J W L Aerts Journal: Eur J Cancer Date: 2012-01-16 Impact factor: 9.162
Authors: Margaret A Tempero; Mokenge P Malafa; E Gabriela Chiorean; Brian Czito; Courtney Scaife; Amol K Narang; Christos Fountzilas; Brian M Wolpin; Mahmoud Al-Hawary; Horacio Asbun; Stephen W Behrman; Al B Benson; Ellen Binder; Dana B Cardin; Charles Cha; Vincent Chung; Mary Dillhoff; Efrat Dotan; Cristina R Ferrone; George Fisher; Jeffrey Hardacre; William G Hawkins; Andrew H Ko; Noelle LoConte; Andrew M Lowy; Cassadie Moravek; Eric K Nakakura; Eileen M O'Reilly; Jorge Obando; Sushanth Reddy; Sarah Thayer; Robert A Wolff; Jennifer L Burns; Griselda Zuccarino-Catania Journal: J Natl Compr Canc Netw Date: 2019-03-01 Impact factor: 11.908
Authors: Ioannis T Konstantinidis; Andrew L Warshaw; Jill N Allen; Lawrence S Blaszkowsky; Carlos Fernandez-Del Castillo; Vikram Deshpande; Theodore S Hong; Eunice L Kwak; Gregory Y Lauwers; David P Ryan; Jennifer A Wargo; Keith D Lillemoe; Cristina R Ferrone Journal: Ann Surg Date: 2013-04 Impact factor: 12.969
Authors: Calogero Casà; Antonio Piras; Andrea D'Aviero; Francesco Preziosi; Silvia Mariani; Davide Cusumano; Angela Romano; Ivo Boskoski; Jacopo Lenkowicz; Nicola Dinapoli; Francesco Cellini; Maria Antonietta Gambacorta; Vincenzo Valentini; Gian Carlo Mattiucci; Luca Boldrini Journal: Ther Adv Gastrointest Endosc Date: 2022-03-16