| Literature DB >> 31932804 |
Jun Liu1,2, Lies Lahousse3,4, Michel G Nivard5,6, Mariska Bot5,6, Lianmin Chen7,8, Jan Bert van Klinken9,10,11, Carisha S Thesing5,6, Marian Beekman12, Erik Ben van den Akker12,13,14, Roderick C Slieker6,15,16, Eveline Waterham17, Carla J H van der Kallen18,19, Irene de Boer20, Ruifang Li-Gao21, Dina Vojinovic3, Najaf Amin3, Djawad Radjabzadeh22, Robert Kraaij22, Louise J M Alferink23, Sarwa Darwish Murad23, André G Uitterlinden3,22, Gonneke Willemsen5,6, Rene Pool5,6, Yuri Milaneschi5,6, Diana van Heemst24, H Eka D Suchiman12, Femke Rutters6,15, Petra J M Elders6,25, Joline W J Beulens6,15, Amber A W A van der Heijden6,25, Marleen M J van Greevenbroek18,19, Ilja C W Arts19,26,27, Gerrit L J Onderwater20, Arn M J M van den Maagdenberg9,20, Dennis O Mook-Kanamori21,28, Thomas Hankemeier29,30, Gisela M Terwindt20, Coen D A Stehouwer18,19, Johanna M Geleijnse17, Leen M 't Hart6,12,15,16, P Eline Slagboom12, Ko Willems van Dijk9,10,31, Alexandra Zhernakova7, Jingyuan Fu7,8, Brenda W J H Penninx5,6, Dorret I Boomsma5,6, Ayşe Demirkan3,7,32, Bruno H C Stricker3,22,33, Cornelia M van Duijn34,35,36.
Abstract
Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug-metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 drug-metabolite associations after evaluation of confounders including co-treatment. We show that the effect estimates of statins on metabolites from the cross-sectional study are comparable to those from intervention and genetic observational studies. Further data integration links proton pump inhibitors to circulating metabolites, liver function, hepatic steatosis and the gut microbiome. Our atlas provides a tool for targeted experimental pharmaceutical research and clinical trials to improve drug efficacy, safety and repurposing. We provide a web-based resource for visualization of the atlas (http://bbmri.researchlumc.nl/atlas/).Entities:
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Year: 2020 PMID： 31932804 DOI： 10.1038/s41591-019-0722-x
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440