Literature DB >> 22436749

Innovation: Metabolomics: the apogee of the omics trilogy.

Gary J Patti1, Oscar Yanes, Gary Siuzdak.   

Abstract

Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping our understanding of cell biology, physiology and medicine.

Entities:  

Mesh：

Year:  2012        PMID： 22436749      PMCID： PMC3682684          DOI： 10.1038/nrm3314

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  67 in total

Review 1.  Metabonomics: a platform for studying drug toxicity and gene function.

Authors:  Jeremy K Nicholson; John Connelly; John C Lindon; Elaine Holmes
Journal:  Nat Rev Drug Discov       Date:  2002-02       Impact factor: 84.694

Review 2.  Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples.

Authors:  Xianlin Han; Richard W Gross
Journal:  Mass Spectrom Rev       Date:  2005 May-Jun       Impact factor: 10.946

3.  Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.

Authors:  Meng-Qiu Dong; John D Venable; Nora Au; Tao Xu; Sung Kyu Park; Daniel Cociorva; Jeffrey R Johnson; Andrew Dillin; John R Yates
Journal:  Science       Date:  2007-08-03       Impact factor: 47.728

4.  Multiple ionization mass spectrometry strategy used to reveal the complexity of metabolomics.

Authors:  Anders Nordström; Elizabeth Want; Trent Northen; Janne Lehtiö; Gary Siuzdak
Journal:  Anal Chem       Date:  2007-12-18       Impact factor: 6.986

Review 5.  Nanostructure-initiator mass spectrometry metabolite analysis and imaging.

Authors:  Matthew P Greving; Gary J Patti; Gary Siuzdak
Journal:  Anal Chem       Date:  2010-11-04       Impact factor: 6.986

6.  Metabolic oxidation regulates embryonic stem cell differentiation.

Authors:  Oscar Yanes; Julie Clark; Diana M Wong; Gary J Patti; Antonio Sánchez-Ruiz; H Paul Benton; Sunia A Trauger; Caroline Desponts; Sheng Ding; Gary Siuzdak
Journal:  Nat Chem Biol       Date:  2010-05-02       Impact factor: 15.040

7.  Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria.

Authors:  Christoph Wittmann; Jens O Krömer; Patrick Kiefer; Tina Binz; Elmar Heinzle
Journal:  Anal Biochem       Date:  2004-04-01       Impact factor: 3.365

8.  Human metabolic profiles are stably controlled by genetic and environmental variation.

Authors:  George Nicholson; Mattias Rantalainen; Anthony D Maher; Jia V Li; Daniel Malmodin; Kourosh R Ahmadi; Johan H Faber; Ingileif B Hallgrímsdóttir; Amy Barrett; Henrik Toft; Maria Krestyaninova; Juris Viksna; Sudeshna Guha Neogi; Marc-Emmanuel Dumas; Ugis Sarkans; Bernard W Silverman; Peter Donnelly; Jeremy K Nicholson; Maxine Allen; Krina T Zondervan; John C Lindon; Tim D Spector; Mark I McCarthy; Elaine Holmes; Dorrit Baunsgaard; Chris C Holmes
Journal:  Mol Syst Biol       Date:  2011-08-30       Impact factor: 11.429

9.  Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks.

Authors:  O Fiehn
Journal:  Comp Funct Genomics       Date:  2001

10.  Highly sensitive feature detection for high resolution LC/MS.

Authors:  Ralf Tautenhahn; Christoph Böttcher; Steffen Neumann
Journal:  BMC Bioinformatics       Date:  2008-11-28       Impact factor: 3.169
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  671 in total

1.  CeCaFDB: a curated database for the documentation, visualization and comparative analysis of central carbon metabolic flux distributions explored by 13C-fluxomics.

Authors:  Zhengdong Zhang; Tie Shen; Bin Rui; Wenwei Zhou; Xiangfei Zhou; Chuanyu Shang; Chenwei Xin; Xiaoguang Liu; Gang Li; Jiansi Jiang; Chao Li; Ruiyuan Li; Mengshu Han; Shanping You; Guojun Yu; Yin Yi; Han Wen; Zhijie Liu; Xiaoyao Xie
Journal:  Nucleic Acids Res       Date:  2014-11-11       Impact factor: 16.971

2.  Warpgroup: increased precision of metabolomic data processing by consensus integration bound analysis.

Authors:  Nathaniel G Mahieu; Jonathan L Spalding; Gary J Patti
Journal:  Bioinformatics       Date:  2015-09-30       Impact factor: 6.937

3.  Real-Time Pure Shift HSQC NMR for Untargeted Metabolomics.

Authors:  István Timári; Cheng Wang; Alexandar L Hansen; Gilson Costa Dos Santos; Sung Ok Yoon; Lei Bruschweiler-Li; Rafael Brüschweiler
Journal:  Anal Chem       Date:  2019-01-16       Impact factor: 6.986

Review 4.  Studies of metabolite-protein interactions: a review.

Authors:  Ryan Matsuda; Cong Bi; Jeanethe Anguizola; Matthew Sobansky; Elliott Rodriguez; John Vargas Badilla; Xiwei Zheng; Benjamin Hage; David S Hage
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2013-11-25       Impact factor: 3.205

Review 5.  Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy.

Authors:  W L Lowe; J Karban
Journal:  Diabet Med       Date:  2014-03       Impact factor: 4.359

Review 6.  An overview of renal metabolomics.

Authors:  Sahir Kalim; Eugene P Rhee
Journal:  Kidney Int       Date:  2016-09-28       Impact factor: 10.612

7.  Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action.

Authors:  Ying Liu; Sanjana Sen; Sivaporn Wannaiampikul; Rengasamy Palanivel; Ruby L C Hoo; Ruth Isserlin; Gary D Bader; Rungsunn Tungtrongchitr; Yves Deshaies; Aimin Xu; Gary Sweeney
Journal:  Biochem J       Date:  2015-04-27       Impact factor: 3.857

8.  Exploring Metabolic Profile Differences between Colorectal Polyp Patients and Controls Using Seemingly Unrelated Regression.

Authors:  Chen Chen; Lingli Deng; Siwei Wei; G A Nagana Gowda; Haiwei Gu; Elena G Chiorean; Mohammad Abu Zaid; Marietta L Harrison; Joseph F Pekny; Patrick J Loehrer; Dabao Zhang; Min Zhang; Daniel Raftery
Journal:  J Proteome Res       Date:  2015-05-13       Impact factor: 4.466

9.  Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.

Authors:  Erik L Allman; Heather J Painter; Jasmeet Samra; Manuela Carrasquilla; Manuel Llinás
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

10.  Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.

Authors:  Shakira M Nelson; Orestis A Panagiotou; Gabriella M Anic; Alison M Mondul; Satu Männistö; Stephanie J Weinstein; Demetrius Albanes
Journal:  Int J Epidemiol       Date:  2016-08-14       Impact factor: 7.196
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