K B Casaletto1, A M Staffaroni1, A Wolf1, B Appleby2, D Brushaber3, G Coppola4, B Dickerson5, K Domoto-Reilly6, F M Elahi1, J Fields3, J C Fong1, L Forsberg2, N Ghoshal7, N Graff-Radford3, M Grossman8, H W Heuer1, G-Y Hsiung9, E D Huey10, D Irwin8, K Kantarci3, D Kaufer11, D Kerwin12, D Knopman3, J Kornak13, J H Kramer1, I Litvan14, I R Mackenzie9, M Mendez4, B Miller1, R Rademakers15, E M Ramos16, K Rascovsky8, E D Roberson17, J A Syrjanen3, M C Tartaglia18, S Weintraub19, B Boeve3, A L Boxer1, H Rosen1, K Yaffe1,20. 1. Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA. 2. Case Western Reserve University, Cleveland, Ohio, USA. 3. Mayo Clinic, Rochester, Minnesota, USA. 4. University of California, Los Angeles, California, USA. 5. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 6. University of Washington, Seattle, Washington, USA. 7. Washington University, St. Louis, Illinois, USA. 8. University of Pennsylvania, Philadelphia, Pennsylvania, USA. 9. University of British Columbia, Vancouver, British Columbia, Canada. 10. Columbia University, New York, New York, USA. 11. University of North Carolina, Chapel Hill, North Carolina, USA. 12. University of Texas Southwestern, Dallas, Texas, USA. 13. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. 14. Parkinson and Other Movement Disorder Center, Department of Neuroscience, University of California, San Diego, San Diego, California, USA. 15. Mayo Clinic, Jacksonville, Florida, USA. 16. University of California, Los Angeles, USA. 17. University of Alabama, Birmingham, Alabama, USA. 18. University of Toronto, Toronto, Ontario, Canada. 19. Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, Illinois, USA. 20. San Francisco Department of Psychiatry, University of California, San Francisco, California, USA.
Abstract
INTRODUCTION: Leisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD). METHODS: A total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline, and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging (MRI) scans. RESULTS: Greater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates. DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.
INTRODUCTION: Leisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD). METHODS: A total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline, and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging (MRI) scans. RESULTS: Greater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates. DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.
Authors: Evan L Thacker; Honglei Chen; Alpa V Patel; Marjorie L McCullough; Eugenia E Calle; Michael J Thun; Michael A Schwarzschild; Alberto Ascherio Journal: Mov Disord Date: 2008-01 Impact factor: 10.338
Authors: Daniel C Aguirre-Acevedo; Francisco Lopera; Eliana Henao; Victoria Tirado; Claudia Muñoz; Margarita Giraldo; Shrikant I Bangdiwala; Eric M Reiman; Pierre N Tariot; Jessica B Langbaum; Yakeel T Quiroz; Fabian Jaimes Journal: JAMA Neurol Date: 2016-04 Impact factor: 18.302
Authors: Laura E Middleton; Todd M Manini; Eleanor M Simonsick; Tamara B Harris; Deborah E Barnes; Frances Tylavsky; Jennifer S Brach; James E Everhart; Kristine Yaffe Journal: Arch Intern Med Date: 2011-07-19
Authors: Prashanthi Vemuri; Timothy G Lesnick; Scott A Przybelski; Mary Machulda; David S Knopman; Michelle M Mielke; Rosebud O Roberts; Yonas E Geda; Walter A Rocca; Ronald C Petersen; Clifford R Jack Journal: JAMA Neurol Date: 2014-08 Impact factor: 18.302
Authors: Yaakov Stern; Eider M Arenaza-Urquijo; David Bartrés-Faz; Sylvie Belleville; Marc Cantilon; Gael Chetelat; Michael Ewers; Nicolai Franzmeier; Gerd Kempermann; William S Kremen; Ozioma Okonkwo; Nikolaos Scarmeas; Anja Soldan; Chinedu Udeh-Momoh; Michael Valenzuela; Prashanthi Vemuri; Eero Vuoksimaa Journal: Alzheimers Dement Date: 2020-01-06 Impact factor: 21.566
Authors: Taylor J Krivanek; Seth A Gale; Brittany M McFeeley; Casey M Nicastri; Kirk R Daffner Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: Kaitlin B Casaletto; Cutter A Lindbergh; Anna VandeBunte; John Neuhaus; Julie A Schneider; Aron S Buchman; William G Honer; David A Bennett Journal: J Neurosci Date: 2021-11-22 Impact factor: 6.709
Authors: Kaarin J Anstey; Ruth Peters; Lidan Zheng; Deborah E Barnes; Carol Brayne; Henry Brodaty; John Chalmers; Linda Clare; Roger A Dixon; Hiroko Dodge; Nicola T Lautenschlager; Laura E Middleton; Chengxuan Qiu; Glenn Rees; Suzana Shahar; Kristine Yaffe Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472