Muneer Abbas1,2, Tshela Mason2, Aliza Ibad2, Mozna Khraiwesh3, Victor Apprey2, Yasmine Kanaan4, Bradford Wilson2, Georgia Dunston4, Luisel Ricks-Santi5, Hassan Brim6. 1. Department of Microbiology, Howard University, Washington, DC, U.S.A. m_abbas@howard.edu. 2. The National Human Genome Center, Howard University, Washington, DC, U.S.A. 3. Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, U.S.A. 4. Department of Microbiology, Howard University, Washington, DC, U.S.A. 5. Cancer Research Center, Hampton University, Hampton, VA, U.S.A. 6. Department of Pathology, Howard University College of Medicine, Washington, DC, U.S.A.
Abstract
BACKGROUND/AIM: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. MATERIALS AND METHODS: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data. RESULTS: rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer. CONCLUSION: IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression. Copyright
BACKGROUND/AIM: Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the association of five SNPs in the IL-10 promoter with clinical features such as Gleason score and smoking. MATERIALS AND METHODS: A total of 413 DNA samples were obtained from a nested case-control study of African American males who were genotyped for 5 SNPs utilizing pyrosequencing. Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data. RESULTS:rs12122923 and rs1800871 were associated with PCa risk. Smoking was also found to increase the risk of PCa by 1.6-fold. rs1800893 was found to be associated with lower grades for prostate cancer. CONCLUSION:IL-10 promoter polymorphisms might be a risk factor for PCa development in smoking subjects and PCa progression. Copyright
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