Riku Erkkola1, Riitta Turunen2, Kati Räisänen3, Matti Waris4, Tytti Vuorinen4, Miia Laine5, Paula Tähtinen1, James E Gern6, Yury A Bochkov6, Aino Ruohola1, Tuomas Jartti1. 1. From the Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland. 2. Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland. 3. Expert Microbiology Unit, National Institute for Health and Welfare, Helsinki, Finland. 4. Department of Virology, University of Turku, Turku, Finland. 5. Department of Clinical Microbiology, Turku University Hospital, Turku, Finland. 6. Department of Paediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Abstract
BACKGROUND: Rhinovirus is the most common virus causing respiratory tract illnesses in children. Rhinoviruses are classified into species A, B and C. We examined the associations between different rhinovirus species and respiratory illness severity. METHODS: This is a retrospective observational cohort study on confirmed rhinovirus infections in 134 children 3-23 months of age, who were enrolled in 2 prospective studies on bronchiolitis and acute otitis media, respectively, conducted simultaneously in Turku University Hospital, Turku, Finland, between September 2007 and December 2008. RESULTS: Rhinovirus C is the most prevalent species in our study, and it was associated with severe wheezing and febrile illness. We also noted that history of atopic eczema was associated with wheezing. CONCLUSIONS: Our understanding of rhinovirus C as the most pathogenic rhinovirus species was fortified. Existing research supports the idea that atopic characteristics are associated with the severity of the rhinovirus C-induced illness.
BACKGROUND: Rhinovirus is the most common virus causing respiratory tract illnesses in children. Rhinoviruses are classified into species A, B and C. We examined the associations between different rhinovirus species and respiratory illness severity. METHODS: This is a retrospective observational cohort study on confirmed rhinovirus infections in 134 children 3-23 months of age, who were enrolled in 2 prospective studies on bronchiolitis and acute otitis media, respectively, conducted simultaneously in Turku University Hospital, Turku, Finland, between September 2007 and December 2008. RESULTS: Rhinovirus C is the most prevalent species in our study, and it was associated with severe wheezing and febrile illness. We also noted that history of atopic eczema was associated with wheezing. CONCLUSIONS: Our understanding of rhinovirus C as the most pathogenic rhinovirus species was fortified. Existing research supports the idea that atopic characteristics are associated with the severity of the rhinovirus C-induced illness.
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