Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection.Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected much less often than RV-A during both respiratory illnesses and scheduled surveillance visits (P < 0.001, χ2) in older children. The prevalence of neutralizing antibodies to RV-A or RV-C types was low (5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78% vs. 18% for RV-A; P < 0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P < 0.0001), CDHR3 genotype (P < 0.05), and wheezing illnesses (P < 0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time.Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.
Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection.Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected much less often than RV-A during both respiratory illnesses and scheduled surveillance visits (P < 0.001, χ2) in older children. The prevalence of neutralizing antibodies to RV-A or RV-C types was low (5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78% vs. 18% for RV-A; P < 0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P < 0.0001), CDHR3 genotype (P < 0.05), and wheezing illnesses (P < 0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time.Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.
Authors: Robert F Lemanske; Daniel J Jackson; Ronald E Gangnon; Michael D Evans; Zhanhai Li; Peter A Shult; Carol J Kirk; Erik Reisdorf; Kathy A Roberg; Elizabeth L Anderson; Kirstin T Carlson-Dakes; Kiva J Adler; Stephanie Gilbertson-White; Tressa E Pappas; Douglas F Dasilva; Christopher J Tisler; James E Gern Journal: J Allergy Clin Immunol Date: 2005-09 Impact factor: 10.793
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Authors: Yingyuan Sun; Kelly Watters; Marchel G Hill; Qianglin Fang; Yue Liu; Richard J Kuhn; Thomas Klose; Michael G Rossmann; Ann C Palmenberg Journal: Proc Natl Acad Sci U S A Date: 2020-03-09 Impact factor: 11.205
Authors: Yue Liu; Marchel G Hill; Thomas Klose; Zhenguo Chen; Kelly Watters; Yury A Bochkov; Wen Jiang; Ann C Palmenberg; Michael G Rossmann Journal: Proc Natl Acad Sci U S A Date: 2016-07-11 Impact factor: 11.205
Authors: Frederick J Rubner; Daniel J Jackson; Michael D Evans; Ronald E Gangnon; Christopher J Tisler; Tressa E Pappas; James E Gern; Robert F Lemanske Journal: J Allergy Clin Immunol Date: 2016-05-10 Impact factor: 10.793