Mohammad Rostami-Nejad1, Mostafa Rezaei-Tavirani2, Mohammad-Mehdi Zadeh-Esmaeel3, Sina RezaeiTavirani4, Zahra Akbari5, Somayeh Esmaeili6, Farshad Okhovatian7. 1. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 6. Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 7. Physiotherapy Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Introduction: Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery Methods: Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software). The central DEGs were identified and enriched via gene ontology by using Clue GO software. Results: A network including 78 DEGs and 100 neighbors was constructed and STAT1, MX1, ISG15, OAS1, IFIT1, IRF8, OASL, OAS2, and RSAD2 as hubs and STAT1, PTPRC, MX1, IRF8, ISG15, IL6, RORC, SAMSN1, and IFIT1 as bottlenecks were introduced. The cytokine-mediated signaling pathway, interferon gamma signaling, hepatitis C, interferon alpha/beta signaling, and the type I interferon signaling pathway were identified as 5 clusters of biological terms which are related to the central nodes. Conclusion: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.
Introduction: Laser therapy is known as an efficient approach in dermatology surgery. CO2 laser therapy is a gold standard treatment in skin surgery. This study aimed to evaluate the interferons change after CO2 laser surgery Methods: Significant differentially-expressed genes (DEGs) of arm skin after 7 days of treatment by the CO2 laser relative to the controls are downloaded from Gene Expression Omnibus (GEO) and are included in the protein-protein interaction network via a STRING database (an application of Cytoscape software). The central DEGs were identified and enriched via gene ontology by using Clue GO software. Results: A network including 78 DEGs and 100 neighbors was constructed and STAT1, MX1, ISG15, OAS1, IFIT1, IRF8, OASL, OAS2, and RSAD2 as hubs and STAT1, PTPRC, MX1, IRF8, ISG15, IL6, RORC, SAMSN1, and IFIT1 as bottlenecks were introduced. The cytokine-mediated signaling pathway, interferon gamma signaling, hepatitis C, interferon alpha/beta signaling, and the type I interferon signaling pathway were identified as 5 clusters of biological terms which are related to the central nodes. Conclusion: It can be concluded that the cytokine-mediated signaling pathway is the major pathway that is dysregulated after laser application in the treated skin.
Authors: José Carlos Tatmatsu-Rocha; Cleber Ferraresi; Michael R Hamblin; Flávio Damasceno Maia; Nilberto Robson Falcão do Nascimento; Patricia Driusso; Nivaldo Antonio Parizotto Journal: J Photochem Photobiol B Date: 2016-09-12 Impact factor: 6.252
Authors: Dongwon Kim; Ruosi Chen; Mary Sheu; Noori Kim; Sooah Kim; Nasif Islam; Eric M Wier; Gaofeng Wang; Ang Li; Angela Park; Wooyang Son; Benjamin Evans; Victoria Yu; Vicky P Prizmic; Eugene Oh; Zixiao Wang; Jianshi Yu; Weiliang Huang; Nathan K Archer; Zhiqi Hu; Nashay Clemetson; Amanda M Nelson; Anna Chien; Ginette A Okoye; Lloyd S Miller; Gabriel Ghiaur; Sewon Kang; Jace W Jones; Maureen A Kane; Luis A Garza Journal: Nat Commun Date: 2019-06-26 Impact factor: 14.919