Saeed Safari1, Mohammad Rostami-Nejad2, Mostafa Rezaei-Tavirani3, Vahid Mansouri3, Zahra Razzaghi4, Majid Rezaei-Tavirani5. 1. Department of Emergency Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 4. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Firoozabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract
Introduction: The widespread application of lasers in medicine, especially in the treatment of diseases implies more investigations to understand the precious molecular mechanism of the laser effect on the human body. In the present study, the prominent role of HERC6 in response to CO2 Laser therapy of human skin is investigated. Methods: The numbers of 16 gene expression profiles before and after the treatment with the CO2 laser are downloaded from Gene Expression Omnibus (GEO), and differentially-expressed genes (DEGs) are analyzed to find the significant DEGs. Gene ontology analysis revealed that HERC6 and a set of its neighbors played a significant role in response to laser application. Results: The expression changes of 52 significant DEGs were compared via heat map analysis and 27 significant DEGs were introduced as the critical genes which are involved in response to laser irradiation. "Thymidylate kinase activity" among 9 clusters of biological terms was highlighted as an important biological process related to the identified DEGs. HERC2 was proposed as a critical DEG which was related to several essential cellular processes in response to laser application. Conclusion: The findings from the present study indicate that HERC6 and the numbers of its first neighbors are involved in the essential cellular response to laser therapy of human skin.
Introduction: The widespread application of lasers in medicine, especially in the treatment of diseases implies more investigations to understand the precious molecular mechanism of the laser effect on the human body. In the present study, the prominent role of HERC6 in response to CO2 Laser therapy of human skin is investigated. Methods: The numbers of 16 gene expression profiles before and after the treatment with the CO2 laser are downloaded from Gene Expression Omnibus (GEO), and differentially-expressed genes (DEGs) are analyzed to find the significant DEGs. Gene ontology analysis revealed that HERC6 and a set of its neighbors played a significant role in response to laser application. Results: The expression changes of 52 significant DEGs were compared via heat map analysis and 27 significant DEGs were introduced as the critical genes which are involved in response to laser irradiation. "Thymidylate kinase activity" among 9 clusters of biological terms was highlighted as an important biological process related to the identified DEGs. HERC2 was proposed as a critical DEG which was related to several essential cellular processes in response to laser application. Conclusion: The findings from the present study indicate that HERC6 and the numbers of its first neighbors are involved in the essential cellular response to laser therapy of human skin.
Authors: T Passeron; R Genedy; L Salah; T Fusade; G Kositratna; H-J Laubach; L Marini; A Badawi Journal: J Eur Acad Dermatol Venereol Date: 2019-03-14 Impact factor: 6.166
Authors: Dongwon Kim; Ruosi Chen; Mary Sheu; Noori Kim; Sooah Kim; Nasif Islam; Eric M Wier; Gaofeng Wang; Ang Li; Angela Park; Wooyang Son; Benjamin Evans; Victoria Yu; Vicky P Prizmic; Eugene Oh; Zixiao Wang; Jianshi Yu; Weiliang Huang; Nathan K Archer; Zhiqi Hu; Nashay Clemetson; Amanda M Nelson; Anna Chien; Ginette A Okoye; Lloyd S Miller; Gabriel Ghiaur; Sewon Kang; Jace W Jones; Maureen A Kane; Luis A Garza Journal: Nat Commun Date: 2019-06-26 Impact factor: 14.919
Authors: Sasha Babicki; David Arndt; Ana Marcu; Yongjie Liang; Jason R Grant; Adam Maciejewski; David S Wishart Journal: Nucleic Acids Res Date: 2016-05-17 Impact factor: 16.971