Anja C Roden1, Wentao Fang2, Yan Shen3, Brett W Carter4, Darin B White5, Sarah M Jenkins6, Grant M Spears6, Julian R Molina7, Eyal Klang8, Mattia D Segni8, Jeanne B Ackman9, Edward Z Sanchez9, Nicolas Girard10, Engjellush Shumeri10, Marie-Pierre Revel11, Guillaume Chassagnon11, Ami Rubinowitz12, Demetrius Dicks12, Frank Detterbeck13, Jane P Ko14, Conrad B Falkson15, Samantha Sigurdson15, Sabrina Segreto16, Silvana Del Vecchio16, Giovanella Palmieri17, Margaret Ottaviano17, Mirella Marino18, Robert Korst19, Edith M Marom8. 1. Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota. Electronic address: Roden.anja@mayo.edu. 2. Department of Thoracic Surgery, Shanghai Chest Hospital, Jiaotong University Medical School, China. 3. Department of Radiology, Shanghai Chest Hospital, Jiaotong University Medical School, China. 4. Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas. 5. Department of Radiology, Mayo Clinic Rochester, Minnesota. 6. Department of Health Sciences Research, Mayo Clinic Rochester, Minnesota. 7. Department of Oncology; Division of Medical Oncology, Mayo Clinic Rochester, Minnesota. 8. The Chaim Sheba Medical Center, affiliated with the Tel Aviv University, Tel Aviv, Israel. 9. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 10. Curie Montsouris Thorax Institute, Institute Curie, Paris, France. 11. Department of Radiology Cochin hospital, University of Paris, Paris, France. 12. Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut. 13. Section of Thoracic Surgery, Yale School of Medicine, New Haven, Connecticut. 14. NYU Langone Health, NYU School of Medicine, New York, New York. 15. CCSEO and Queen's University, Kingston, Canada. 16. Department of Advanced Biomedical Sciences. University Federico II Naples, Italy. 17. Rare Tumours Reference Center of Campania Region (CRTR), University Federico II of Naples, Naples, Italy. 18. Department of Pathology, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy. 19. Department of Thoracic Surgery, Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, New York; Valley/Mount Sinai Comprehensive Cancer Care, Paramus, New Jersey; Department of Surgery, The Valley Hospital, Ridgewood, New Jersey.
Abstract
INTRODUCTION: Mediastinal lesions are uncommon; studies on their distribution are, in general, small and from a single institution. Furthermore, these studies are usually based on pathology or surgical databases and, therefore, miss many lesions that did not undergo biopsy or resection. Our aim was to identify the distribution of lesions in the mediastinum in a large international, multi-institutional cohort. METHODS: At each participating institution, a standardized retrospective radiology database search was performed for interpretations of computed tomography, positron emission tomography-computed tomography, and magnetic resonance imaging scans including any of the following terms: "mediastinal nodule," "mediastinal lesion," "mediastinal mass," or "mediastinal abnormality" (2011-2014). Standardized data were collected. Statistical analysis was performed. RESULTS: Among 3308 cases, thymomas (27.8%), benign mediastinal cysts (20.0%), and lymphomas (16.1%) were most common. The distribution of lesions varied among mediastinal compartments; thymomas (38.3%), benign cysts (16.8%), and neurogenic tumors (53.9%) were the most common lesions in the prevascular, visceral, and paravertebral mediastinum, respectively (p < 0.001). Mediastinal compartment was associated with age; patients with paravertebral lesions were the youngest (p < 0.0001). Mediastinal lesions differed by continent or country, with benign cysts being the most common mediastinal lesions in the People's Republic of China, thymomas in Europe, and lymphomas in North America and Israel (p < 0.001). Benign cysts, thymic carcinomas, and metastases were more often seen in larger hospitals, whereas lymphomas and thymic hyperplasia occurred more often in smaller hospitals (p < 0.01). CONCLUSIONS: Our study confirmed that the spectrum and frequency of mediastinal lesions depend on mediastinal compartment and age. This information provides helpful demographic data and is important when considering the differential diagnosis of a mediastinal lesion.
INTRODUCTION: Mediastinal lesions are uncommon; studies on their distribution are, in general, small and from a single institution. Furthermore, these studies are usually based on pathology or surgical databases and, therefore, miss many lesions that did not undergo biopsy or resection. Our aim was to identify the distribution of lesions in the mediastinum in a large international, multi-institutional cohort. METHODS: At each participating institution, a standardized retrospective radiology database search was performed for interpretations of computed tomography, positron emission tomography-computed tomography, and magnetic resonance imaging scans including any of the following terms: "mediastinal nodule," "mediastinal lesion," "mediastinal mass," or "mediastinal abnormality" (2011-2014). Standardized data were collected. Statistical analysis was performed. RESULTS: Among 3308 cases, thymomas (27.8%), benign mediastinal cysts (20.0%), and lymphomas (16.1%) were most common. The distribution of lesions varied among mediastinal compartments; thymomas (38.3%), benign cysts (16.8%), and neurogenic tumors (53.9%) were the most common lesions in the prevascular, visceral, and paravertebral mediastinum, respectively (p < 0.001). Mediastinal compartment was associated with age; patients with paravertebral lesions were the youngest (p < 0.0001). Mediastinal lesions differed by continent or country, with benign cysts being the most common mediastinal lesions in the People's Republic of China, thymomas in Europe, and lymphomas in North America and Israel (p < 0.001). Benign cysts, thymic carcinomas, and metastases were more often seen in larger hospitals, whereas lymphomas and thymic hyperplasia occurred more often in smaller hospitals (p < 0.01). CONCLUSIONS: Our study confirmed that the spectrum and frequency of mediastinal lesions depend on mediastinal compartment and age. This information provides helpful demographic data and is important when considering the differential diagnosis of a mediastinal lesion.
Authors: Mounika Angirekula; Sindy Y Chang; Sarah M Jenkins; Patricia T Greipp; William R Sukov; Randolph S Marks; Kenneth R Olivier; Stephen D Cassivi; Anja C Roden Journal: Cancers (Basel) Date: 2022-05-05 Impact factor: 6.575
Authors: Stefan Porubsky; Zoran V Popovic; Sunil Badve; Yara Banz; Sabina Berezowska; Dietmar Borchert; Monika Brüggemann; Timo Gaiser; Thomas Graeter; Peter Hollaus; Katrin S Huettl; Michaela Kotrova; Andreas Kreft; Christian Kugler; Fabian Lötscher; Burkhard Möller; German Ott; Gerhard Preissler; Eric Roessner; Andreas Rosenwald; Philipp Ströbel; Alexander Marx Journal: Cancers (Basel) Date: 2021-01-16 Impact factor: 6.639
Authors: Anja C Roden; Sagar Rakshit; Geoffrey B Johnson; Sarah M Jenkins; Aaron S Mansfield Journal: Front Oncol Date: 2022-02-07 Impact factor: 6.244
Authors: Chengzhou Zhang; Qinglin Yang; Fan Lin; Heng Ma; Haicheng Zhang; Ran Zhang; Ping Wang; Ning Mao Journal: Front Oncol Date: 2021-12-10 Impact factor: 6.244