| Literature DB >> 31870645 |
Jason Langley1, Sana Hussain2, Justino J Flores3, Ilana J Bennett3, Xiaoping Hu4.
Abstract
Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here, we use high-resolution diffusion-weighted MRI to investigate microstructural and compositional changes in LC and SNpc in young and older adult cohorts, as well as their relationship with cognition. In LC, the older cohort exhibited a significant reduction in mean and radial diffusivity, but a significant increase in fractional anisotropy compared with the young cohort. We observed a significant correlation between the decrease in LC mean, axial, and radial diffusivities and measures examining cognition (Rey Auditory Verbal Learning Test delayed recall) in the older adult cohort. This observation suggests that LC is involved in retaining cognitive abilities. In addition, we observed that iron deposition in SNpc occurs early in life and continues during normal aging.Entities:
Keywords: Aging; DTI; Iron deposition; Locus coeruleus; Substantia nigra
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Year: 2019 PMID： 31870645 PMCID： PMC7064384 DOI： 10.1016/j.neurobiolaging.2019.11.016
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673