Jason Langley1, Naying He2, Daniel E Huddleston3, Shengdi Chen4, Fuhua Yan2, Bruce Crosson3,5,6, Stewart Factor3, Xiaoping Hu1,7. 1. Center for Advanced Neuroimaging, University of California, Riverside, Riverside, California, USA. 2. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3. Department of Neurology, Emory University, Atlanta, Georgia, USA. 4. Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5. Department of Veterans Affairs Center for Visual and Neurocognitive Rehabilitation, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA. 6. Department of Psychology, Georgia State University, Atlanta, Georgia, USA. 7. Department of Bioengineering, University of California, Riverside, Riverside, California, USA.
Abstract
BACKGROUND: Previous studies investigating nigral iron accumulation used T2 or T2 *-weighted contrasts to define the regions of interest (ROIs) in the substantia nigra with mixed results. Because these contrasts are not sensitive to neuromelanin, ROIs may have inadvertently missed the SNpc. An approach sensitive to neuromelanin should yield consistent results. We examine iron deposition in ROIs derived from neuromelanin-sensitive and T2 *-weighted contrasts, respectively. METHODS: T1 -weighted and multiecho gradient echo imaging data were obtained in 2 cohorts. Multiecho gradient echo imaging data were analyzed using neuromelanin-sensitive SNpc ROIs as well as T2 *-weighted SNr ROIs. RESULTS: When compared with controls, significantly larger R2 * values were seen in the SNpc of PD patients in both cohorts. Mean R2 * values in the SNr of PD patients showed no consistency, with 1 cohort showing a small, statistically significant increase, whereas the other cohort exhibited no statistical difference. CONCLUSION: Mean R2 * in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD.
BACKGROUND: Previous studies investigating nigraliron accumulation used T2 or T2 *-weighted contrasts to define the regions of interest (ROIs) in the substantia nigra with mixed results. Because these contrasts are not sensitive to neuromelanin, ROIs may have inadvertently missed the SNpc. An approach sensitive to neuromelanin should yield consistent results. We examine iron deposition in ROIs derived from neuromelanin-sensitive and T2 *-weighted contrasts, respectively. METHODS: T1 -weighted and multiecho gradient echo imaging data were obtained in 2 cohorts. Multiecho gradient echo imaging data were analyzed using neuromelanin-sensitive SNpc ROIs as well as T2 *-weighted SNr ROIs. RESULTS: When compared with controls, significantly larger R2 * values were seen in the SNpc of PDpatients in both cohorts. Mean R2 * values in the SNr of PDpatients showed no consistency, with 1 cohort showing a small, statistically significant increase, whereas the other cohort exhibited no statistical difference. CONCLUSION: Mean R2 * in the SNpc defined by neuromelanin-sensitive MRI is significantly increased in PD.
Authors: Lauren I Wallis; Martyn N J Paley; Jacqueline M Graham; Richard A Grünewald; Emma L Wignall; Harriet M Joy; Paul D Griffiths Journal: J Magn Reson Imaging Date: 2008-11 Impact factor: 4.813
Authors: Jason Langley; Daniel E Huddleston; Bruce Crosson; David D Song; Stewart A Factor; Xiaoping Hu Journal: Parkinsonism Relat Disord Date: 2020-09-16 Impact factor: 4.891