| Literature DB >> 31866441 |
Ahmad Al-Mrabeh1, Sviatlana V Zhyzhneuskaya2, Carl Peters2, Alison C Barnes3, Shaden Melhem2, Aaron Jesuthasan4, Benjamin Aribisala5, Kieren G Hollingsworth2, Georg Lietz3, John C Mathers3, Naveed Sattar6, Michael E J Lean7, Roy Taylor8.
Abstract
The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intra-pancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and β-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes.Entities:
Keywords: VLDL1-triglycerides; diabetes remission; human; intra-pancreatic fat; liver fat; palmitic acid; pathophysiology; twin cycle hypothesis; type 2 diabetes; β-cell function
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Year: 2019 PMID： 31866441 DOI： 10.1016/j.cmet.2019.11.018
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287