| Literature DB >> 34671102 |
Robert Wagner1,2,3, Sabine S Eckstein1,2, Hajime Yamazaki4, Felicia Gerst1,2,3, Jürgen Machann1,2,5, Benjamin Assad Jaghutriz1,2,3, Annette Schürmann2,6,7, Michele Solimena2,8,9, Stephan Singer10, Alfred Königsrainer11, Andreas L Birkenfeld1,2,3, Hans-Ulrich Häring1,2,3, Andreas Fritsche1,2,3, Susanne Ullrich1,2,3, Martin Heni12,13,14,15.
Abstract
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.Entities:
Mesh：
Year: 2021 PMID： 34671102 DOI： 10.1038/s41574-021-00573-3
Source DB: PubMed Journal: Nat Rev Endocrinol ISSN： 1759-5029 Impact factor: 43.330