Literature DB >> 31844012

Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Trang T T Vu1, Nhu T Q Nguyen1, Vuvi G Tran1, Emmanuelle Gras1,2, Yanjie Mao1,3, David H Jung1, Christine Tkaczyk4, Bret R Sellman5, Binh An Diep6.   

Abstract

Staphylococcus aureus is a major human pathogen that causes a wide range of infections by producing an arsenal of cytotoxins. We found that passive immunization with either a monoclonal antibody (MAb) neutralizing alpha-hemolysin or a broadly cross-reactive MAb neutralizing Panton-Valentine leukocidin, leukocidin ED, and gamma-hemolysins HlgAB and HlgCB conferred only partial protection, whereas the combination of those two MAbs conferred significant protection in a rabbit model of necrotizing pneumonia caused by the USA300 methicillin-resistant S. aureus epidemic clone.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  Staphylococcus aureus; acute lung inflammation; necrotizing pneumonia; therapeutic antibodies

Mesh：

Substances：

Year:  2020        PMID： 31844012      PMCID： PMC7038280          DOI： 10.1128/AAC.02220-19

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

Review 1.  Antibacterial drug discovery: is it all downhill from here?

Authors:  S J Projan; D M Shlaes
Journal:  Clin Microbiol Infect       Date:  2004-11       Impact factor: 8.067

Review 2.  Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.

Authors:  András N Spaan; Jos A G van Strijp; Victor J Torres
Journal:  Nat Rev Microbiol       Date:  2017-04-19       Impact factor: 60.633

3.  Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.

Authors:  Binh An Diep; Liana Chan; Pierre Tattevin; Osamu Kajikawa; Thomas R Martin; Li Basuino; Thuy T Mai; Helene Marbach; Kevin R Braughton; Adeline R Whitney; Donald J Gardner; Xuemo Fan; Ching W Tseng; George Y Liu; Cedric Badiou; Jerome Etienne; Gerard Lina; Michael A Matthay; Frank R DeLeo; Henry F Chambers
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-15       Impact factor: 11.205

4.  MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

Authors:  L Hua; T S Cohen; Y Shi; V Datta; J J Hilliard; C Tkaczyk; J Suzich; C K Stover; B R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2015-05-18       Impact factor: 5.191

5.  Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

Authors:  Binh An Diep; Jamese J Hilliard; Vien T M Le; Christine Tkaczyk; Hoan N Le; Vuvi G Tran; Renee L Rao; Etyene Castro Dip; Eliane P Pereira-Franchi; Paulyn Cha; Scott Jacobson; Rosemary Broome; Lily I Cheng; William Weiss; Laszlo Prokai; Vien Nguyen; C Ken Stover; Bret R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

6.  IVIG-mediated protection against necrotizing pneumonia caused by MRSA.

Authors:  Binh An Diep; Vien T M Le; Cedric Badiou; Hoan N Le; Marcos Gabriel Pinheiro; Au H Duong; Xing Wang; Etyene Castro Dip; Fábio Aguiar-Alves; Li Basuino; Helene Marbach; Thuy T Mai; Marie N Sarda; Osamu Kajikawa; Gustavo Matute-Bello; Christine Tkaczyk; Jean-Philippe Rasigade; Bret R Sellman; Henry F Chambers; Gerard Lina
Journal:  Sci Transl Med       Date:  2016-09-21       Impact factor: 17.956

Review 7.  Waves of resistance: Staphylococcus aureus in the antibiotic era.

Authors:  Henry F Chambers; Frank R Deleo
Journal:  Nat Rev Microbiol       Date:  2009-09       Impact factor: 60.633

8.  Passive immunization with antiserum to a nontoxic alpha-toxin mutant from Staphylococcus aureus is protective in a murine model.

Authors:  B E Menzies; D S Kernodle
Journal:  Infect Immun       Date:  1996-05       Impact factor: 3.441

9.  Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults.

Authors:  Xiang-Qing Yu; Gabriel J Robbie; Yuling Wu; Mark T Esser; Kathryn Jensen; Howard I Schwartz; Terramika Bellamy; Martha Hernandez-Illas; Hasan S Jafri
Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

10.  Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Authors:  C Tkaczyk; S Kasturirangan; A Minola; O Jones-Nelson; V Gunter; Y Y Shi; K Rosenthal; V Aleti; E Semenova; P Warrener; D Tabor; C K Stover; D Corti; G Rainey; B R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191
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  8 in total

1.  Mucosa-Associated Invariant T Cell Hypersensitivity to Staphylococcus aureus Leukocidin ED and Its Modulation by Activation.

Authors:  Caroline Boulouis; Edwin Leeansyah; Srikanth Mairpady Shambat; Anna Norrby-Teglund; Johan K Sandberg
Journal:  J Immunol       Date:  2022-02-09       Impact factor: 5.426

2.  Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection.

Authors:  Yanjie Mao; Florent Valour; Nhu T Q Nguyen; Thien M N Doan; Holly Koelkebeck; Christopher Richardson; Lily I Cheng; Bret R Sellman; Christine Tkaczyk; Binh An Diep
Journal:  Antimicrob Agents Chemother       Date:  2021-06-17       Impact factor: 5.191

3.  Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case.

Authors:  Enrico König; Assunta Gagliardi; Ilary Riedmiller; Chiara Andretta; Michele Tomasi; Carmela Irene; Luca Frattini; Ilaria Zanella; Francesco Berti; Alberto Grandi; Elena Caproni; Laura Fantappiè; Guido Grandi
Journal:  Front Immunol       Date:  2021-11-08       Impact factor: 7.561

Review 4.  Staphylococcus aureus, Antibiotic Resistance, and the Interaction with Human Neutrophils.

Authors:  Viktoria Rungelrath; Frank R DeLeo
Journal:  Antioxid Redox Signal       Date:  2020-06-23       Impact factor: 8.401

Review 5.  Staphylococcus aureus Arsenal To Conquer the Lower Respiratory Tract.

Authors:  Mariane Pivard; Karen Moreau; François Vandenesch
Journal:  mSphere       Date:  2021-05-19       Impact factor: 4.389

Review 6.  Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens.

Authors:  Daniel V Zurawski; Molly K McLendon
Journal:  Antibiotics (Basel)       Date:  2020-04-01

Review 7.  Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia.

Authors:  Jelle Vlaeminck; Dina Raafat; Kristin Surmann; Leen Timbermont; Nicole Normann; Bret Sellman; Willem J B van Wamel; Surbhi Malhotra-Kumar
Journal:  Toxins (Basel)       Date:  2020-11-18       Impact factor: 4.546

Review 8.  Pore-Forming Toxins During Bacterial Infection: Molecular Mechanisms and Potential Therapeutic Targets.

Authors:  Haijie Hu; Min Liu; Shuang Sun
Journal:  Drug Des Devel Ther       Date:  2021-09-07       Impact factor: 4.162
  8 in total

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