Literature DB >> 33903108

Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection.

Yanjie Mao1,2, Florent Valour1,3,4, Nhu T Q Nguyen1, Thien M N Doan1, Holly Koelkebeck5, Christopher Richardson6, Lily I Cheng5, Bret R Sellman6, Christine Tkaczyk6, Binh An Diep1.   

Abstract

In a rabbit model of methicillin-resistant Staphylococcus aureus prosthetic joint infection (PJI), prophylaxis with AZD6389*-a combination of three monoclonal antibodies targeting alpha-hemolysin, bicomponent cytotoxins (LukSF/LukED/HlgAB/HlgCB), and clumping factor A-resulted in significant reductions in joint swelling, erythema, intra-articular pus, and bacterial burden in synovial tissues and biofilm-associated prosthetic implants compared with isotype-matched control IgG. Targeting specific staphylococcal virulence factors may thus have potential clinical utility for prevention of PJI.

Entities:  

Keywords:  Staphylococcus aureus; alpha-toxin; clumping factor A; leukocidin; monoclonal antibody; prosthetic joint infection

Mesh：

Substances：

Year:  2021        PMID： 33903108      PMCID： PMC8218614          DOI： 10.1128/AAC.01832-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Projected Volume of Primary Total Joint Arthroplasty in the U.S., 2014 to 2030.

Authors:  Matthew Sloan; Ajay Premkumar; Neil P Sheth
Journal:  J Bone Joint Surg Am       Date:  2018-09-05       Impact factor: 5.284

Review 2.  Leukocidins: staphylococcal bi-component pore-forming toxins find their receptors.

Authors:  András N Spaan; Jos A G van Strijp; Victor J Torres
Journal:  Nat Rev Microbiol       Date:  2017-04-19       Impact factor: 60.633

3.  Protective Efficacy of Monoclonal Antibodies Neutralizing Alpha-Hemolysin and Bicomponent Leukocidins in a Rabbit Model of Staphylococcus aureus Necrotizing Pneumonia.

Authors:  Trang T T Vu; Nhu T Q Nguyen; Vuvi G Tran; Emmanuelle Gras; Yanjie Mao; David H Jung; Christine Tkaczyk; Bret R Sellman; Binh An Diep
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191

4.  A novel total knee arthroplasty infection model in rabbits.

Authors:  Matthew R Craig; Kornelis A Poelstra; J Christopher Sherrell; Michael S Kwon; Etienne L Belzile; Thomas E Brown
Journal:  J Orthop Res       Date:  2005-09       Impact factor: 3.494

5.  Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study.

Authors:  C Triffault-Fillit; T Ferry; F Laurent; P Pradat; C Dupieux; A Conrad; A Becker; S Lustig; M H Fessy; C Chidiac; F Valour
Journal:  Clin Microbiol Infect       Date:  2018-05-25       Impact factor: 8.067

6.  Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury.

Authors:  Binh An Diep; Liana Chan; Pierre Tattevin; Osamu Kajikawa; Thomas R Martin; Li Basuino; Thuy T Mai; Helene Marbach; Kevin R Braughton; Adeline R Whitney; Donald J Gardner; Xuemo Fan; Ching W Tseng; George Y Liu; Cedric Badiou; Jerome Etienne; Gerard Lina; Michael A Matthay; Frank R DeLeo; Henry F Chambers
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-15       Impact factor: 11.205

7.  Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

Authors:  Binh An Diep; Jamese J Hilliard; Vien T M Le; Christine Tkaczyk; Hoan N Le; Vuvi G Tran; Renee L Rao; Etyene Castro Dip; Eliane P Pereira-Franchi; Paulyn Cha; Scott Jacobson; Rosemary Broome; Lily I Cheng; William Weiss; Laszlo Prokai; Vien Nguyen; C Ken Stover; Bret R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

8.  IVIG-mediated protection against necrotizing pneumonia caused by MRSA.

Authors:  Binh An Diep; Vien T M Le; Cedric Badiou; Hoan N Le; Marcos Gabriel Pinheiro; Au H Duong; Xing Wang; Etyene Castro Dip; Fábio Aguiar-Alves; Li Basuino; Helene Marbach; Thuy T Mai; Marie N Sarda; Osamu Kajikawa; Gustavo Matute-Bello; Christine Tkaczyk; Jean-Philippe Rasigade; Bret R Sellman; Henry F Chambers; Gerard Lina
Journal:  Sci Transl Med       Date:  2016-09-21       Impact factor: 17.956

Review 9.  Staphylococcus aureus α-toxin: nearly a century of intrigue.

Authors:  Bryan J Berube; Juliane Bubeck Wardenburg
Journal:  Toxins (Basel)       Date:  2013-06       Impact factor: 4.546

10.  Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Authors:  C Tkaczyk; S Kasturirangan; A Minola; O Jones-Nelson; V Gunter; Y Y Shi; K Rosenthal; V Aleti; E Semenova; P Warrener; D Tabor; C K Stover; D Corti; G Rainey; B R Sellman
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191
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  4 in total

1.  Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound.

Authors:  Christine Tkaczyk; Omari Jones-Nelson; Yue Yue Shi; David E Tabor; Lily Cheng; Tianhui Zhang; Bret R Sellman
Journal:  mSphere       Date:  2022-06-01       Impact factor: 5.029

Review 2.  Skeletal infections: microbial pathogenesis, immunity and clinical management.

Authors:  Elysia A Masters; Benjamin F Ricciardi; Karen L de Mesy Bentley; T Fintan Moriarty; Edward M Schwarz; Gowrishankar Muthukrishnan
Journal:  Nat Rev Microbiol       Date:  2022-02-15       Impact factor: 78.297

3.  The dynamic transcriptome during maturation of biofilms formed by methicillin-resistant Staphylococcus aureus.

Authors:  Jelle Vlaeminck; Qiang Lin; Basil Britto Xavier; Sarah De Backer; Matilda Berkell; Henri De Greve; Jean-Pierre Hernalsteens; Samir Kumar-Singh; Herman Goossens; Surbhi Malhotra-Kumar
Journal:  Front Microbiol       Date:  2022-07-28       Impact factor: 6.064

Review 4.  Molecular Targets for Antibody-Based Anti-Biofilm Therapy in Infective Endocarditis.

Authors:  Jiahe Han; Alessandro Poma
Journal:  Polymers (Basel)       Date:  2022-08-05       Impact factor: 4.967
  4 in total

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