Literature DB >> 31823686

The role of enhancer RNAs in epigenetic regulation of gene expression.

Homa Rahnamoun1, Paola Orozco1, Shannon M Lauberth1.   

Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Keywords:  BRD4; Enhancer; bromodomain; chromatin; eRNA; gene regulation; histone modification; transcription

Year:  2019        PMID： 31823686      PMCID： PMC7053929          DOI： 10.1080/21541264.2019.1698934

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  78 in total

1.  RNA Binding to CBP Stimulates Histone Acetylation and Transcription.

Authors:  Daniel A Bose; Greg Donahue; Danny Reinberg; Ramin Shiekhattar; Roberto Bonasio; Shelley L Berger
Journal:  Cell       Date:  2017-01-12       Impact factor: 41.582

2.  NF-κB directs dynamic super enhancer formation in inflammation and atherogenesis.

Authors:  Jonathan D Brown; Charles Y Lin; Qiong Duan; Gabriel Griffin; Alexander Federation; Ronald M Paranal; Steven Bair; Gail Newton; Andrew Lichtman; Andrew Kung; Tianlun Yang; Hong Wang; Francis W Luscinskas; Kevin Croce; James E Bradner; Jorge Plutzky
Journal:  Mol Cell       Date:  2014-09-25       Impact factor: 17.970

3.  Systematic localization of common disease-associated variation in regulatory DNA.

Authors:  Matthew T Maurano; Richard Humbert; Eric Rynes; Robert E Thurman; Eric Haugen; Hao Wang; Alex P Reynolds; Richard Sandstrom; Hongzhu Qu; Jennifer Brody; Anthony Shafer; Fidencio Neri; Kristen Lee; Tanya Kutyavin; Sandra Stehling-Sun; Audra K Johnson; Theresa K Canfield; Erika Giste; Morgan Diegel; Daniel Bates; R Scott Hansen; Shane Neph; Peter J Sabo; Shelly Heimfeld; Antony Raubitschek; Steven Ziegler; Chris Cotsapas; Nona Sotoodehnia; Ian Glass; Shamil R Sunyaev; Rajinder Kaul; John A Stamatoyannopoulos
Journal:  Science       Date:  2012-09-05       Impact factor: 47.728

4.  Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Authors:  Alan C Mullen; David A Orlando; Jamie J Newman; Jakob Lovén; Roshan M Kumar; Steve Bilodeau; Jessica Reddy; Matthew G Guenther; Rodney P DeKoter; Richard A Young
Journal:  Cell       Date:  2011-10-28       Impact factor: 41.582

5.  Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.

Authors:  Kyoko L Yap; Side Li; Ana M Muñoz-Cabello; Selina Raguz; Lei Zeng; Shiraz Mujtaba; Jesús Gil; Martin J Walsh; Ming-Ming Zhou
Journal:  Mol Cell       Date:  2010-06-11       Impact factor: 17.970

Review 6.  Enhancer deregulation in cancer and other diseases.

Authors:  Hans-Martin Herz
Journal:  Bioessays       Date:  2016-08-29       Impact factor: 4.345

7.  Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA.

Authors:  Z Zou; B Huang; X Wu; H Zhang; J Qi; J Bradner; S Nair; L-F Chen
Journal:  Oncogene       Date:  2013-05-20       Impact factor: 9.867

8.  Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.

Authors:  Yu Zhao; Liguo Wang; Shancheng Ren; Lan Wang; Patrick R Blackburn; Melissa S McNulty; Xu Gao; Meng Qiao; Robert L Vessella; Manish Kohli; Jun Zhang; R Jeffrey Karnes; Donald J Tindall; Youngsoo Kim; Robert MacLeod; Stephen C Ekker; Tiebang Kang; Yinghao Sun; Haojie Huang
Journal:  Cell Rep       Date:  2016-04-07       Impact factor: 9.423

9.  Cooperative binding of two acetylation marks on a histone tail by a single bromodomain.

Authors:  Jeanne Morinière; Sophie Rousseaux; Ulrich Steuerwald; Montserrat Soler-López; Sandrine Curtet; Anne-Laure Vitte; Jérôme Govin; Jonathan Gaucher; Karin Sadoul; Darren J Hart; Jeroen Krijgsveld; Saadi Khochbin; Christoph W Müller; Carlo Petosa
Journal:  Nature       Date:  2009-10-01       Impact factor: 49.962

10.  Landscape of transcription in human cells.

Authors:  Sarah Djebali; Carrie A Davis; Angelika Merkel; Alex Dobin; Timo Lassmann; Ali Mortazavi; Andrea Tanzer; Julien Lagarde; Wei Lin; Felix Schlesinger; Chenghai Xue; Georgi K Marinov; Jainab Khatun; Brian A Williams; Chris Zaleski; Joel Rozowsky; Maik Röder; Felix Kokocinski; Rehab F Abdelhamid; Tyler Alioto; Igor Antoshechkin; Michael T Baer; Nadav S Bar; Philippe Batut; Kimberly Bell; Ian Bell; Sudipto Chakrabortty; Xian Chen; Jacqueline Chrast; Joao Curado; Thomas Derrien; Jorg Drenkow; Erica Dumais; Jacqueline Dumais; Radha Duttagupta; Emilie Falconnet; Meagan Fastuca; Kata Fejes-Toth; Pedro Ferreira; Sylvain Foissac; Melissa J Fullwood; Hui Gao; David Gonzalez; Assaf Gordon; Harsha Gunawardena; Cedric Howald; Sonali Jha; Rory Johnson; Philipp Kapranov; Brandon King; Colin Kingswood; Oscar J Luo; Eddie Park; Kimberly Persaud; Jonathan B Preall; Paolo Ribeca; Brian Risk; Daniel Robyr; Michael Sammeth; Lorian Schaffer; Lei-Hoon See; Atif Shahab; Jorgen Skancke; Ana Maria Suzuki; Hazuki Takahashi; Hagen Tilgner; Diane Trout; Nathalie Walters; Huaien Wang; John Wrobel; Yanbao Yu; Xiaoan Ruan; Yoshihide Hayashizaki; Jennifer Harrow; Mark Gerstein; Tim Hubbard; Alexandre Reymond; Stylianos E Antonarakis; Gregory Hannon; Morgan C Giddings; Yijun Ruan; Barbara Wold; Piero Carninci; Roderic Guigó; Thomas R Gingeras
Journal:  Nature       Date:  2012-09-06       Impact factor: 49.962
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  6 in total

1.  Transcriptional control by enhancers: working remotely for improved performance.

Authors:  Joaquin M Espinosa
Journal:  Transcription       Date:  2020-02

Review 2.  The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead.

Authors:  Vemparthan Suvekbala; Haribaskar Ramachandran; Alaguraj Veluchamy; Mariano A Bruno Mascarenhas; Tharmarajan Ramprasath; M K C Nair; Venkata Naga Srikanth Garikipati; Rohit Gundamaraju; Ramasamy Subbiah
Journal:  Neuromolecular Med       Date:  2022-09-24       Impact factor: 4.103

3.  Genomics, molecular and evolutionary perspective of NAC transcription factors.

Authors:  Tapan Kumar Mohanta; Dhananjay Yadav; Adil Khan; Abeer Hashem; Baby Tabassum; Abdul Latif Khan; Elsayed Fathi Abd Allah; Ahmed Al-Harrasi
Journal:  PLoS One       Date:  2020-04-10       Impact factor: 3.240

Review 4.  The pleiotropic roles of SPT5 in transcription.

Authors:  Aixia Song; Fei Xavier Chen
Journal:  Transcription       Date:  2022-07-25

Review 5.  Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis.

Authors:  Shimaa Hassan AbdelAziz Soliman; Arturo Orlacchio; Fabio Verginelli
Journal:  Microorganisms       Date:  2021-05-30

Review 6.  Non-Coding RNA Editing in Cancer Pathogenesis.

Authors:  Giulia Romano; Michela Saviana; Patricia Le; Howard Li; Lavender Micalo; Giovanni Nigita; Mario Acunzo; Patrick Nana-Sinkam
Journal:  Cancers (Basel)       Date:  2020-07-08       Impact factor: 6.639
  6 in total

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