| Literature DB >> 31815449 |
Yao-Bing Huang1,2, Wenlong Cai2, Antonio Del Rio Flores2, Frederick F Twigg2, Wenjun Zhang2.
Abstract
A facile method for the quick discovery and quantification of isonitrile compounds from microbial cultures was established based on the isonitrile-tetrazine click reaction. This method was successfully applied to the rediscovery of diisonitrile antibotic SF2768 from an unknown strain Streptomyces tsukubensis. Finally, an in situ reduction further enabled bioorthogonal ligation of primary and secondary isonitriles for the first time.Entities:
Mesh:
Substances:
Year: 2019 PMID: 31815449 PMCID: PMC7718942 DOI: 10.1021/acs.analchem.9b05147
Source DB: PubMed Journal: Anal Chem ISSN: 0003-2700 Impact factor: 6.986