| Literature DB >> 9592568 |
T Sugawara1, A Tanaka, H Imai, K Nagai, K Suzuki.
Abstract
During the course of our screening for new antibiotics, Micromonospora echinospora subsp. echinospora Y-03559J was found to produce a novel isonitrile compound, YM-47515 (1) along with a probable degradation product 2. The structure of 1 was assigned by spectroscopic analysis including 2D NMR and IR experiments. The relative stereochemistry of 1 was also proposed by comparison of spectral data with those of a closely related compound aerocyanidin (3). YM-47515 (1) showed promising antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).Entities:
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Year: 1997 PMID： 9592568 DOI： 10.7164/antibiotics.50.944
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649