Literature DB >> 31815035

PGK1-mediated cancer progression and drug resistance.

Yu He1, Yang Luo1, Dan Zhang1, Xixi Wang1, Peng Zhang2, Haocheng Li3, Samina Ejaz4, Shufang Liang1.   

Abstract

Phosphoglycerate kinase 1 (PGK1) is an essential enzyme in the aerobic glycolysis pathway. PGK1 catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP and produces 3-phosphoglycerate and ATP. In addition to cell metabolism regulation, PGK1 is involved in multiple biological activities, including angiogenesis, autophagy and DNA repair. Because of its multi-faceted functions, PGK1's involvement in cancer development is complicated. High intracellular expression of PGK1 leads to tumor cell proliferation. However, high extracellular expression of PGK1 suppresses cancer malignancy through a suppression of angiogenesis. PGK1 is also associated with chemoradiotherapy resistance and poor prognosis of cancer patients. In this manuscript, we summarize the influence of PGK1 and its post-translational modifications on cancer initiation and progression. PGK1-mediated drug resistance and potential small molecule inhibitors targeting PGK1 are discussed for their future clinical applications. AJCR
Copyright © 2019.

Entities:  

Keywords:  PGK1; cancer; drug resistance; post-translational modification; small molecule inhibitors

Year:  2019        PMID： 31815035      PMCID： PMC6895440     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  99 in total

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Journal:  Cell Cycle       Date:  2016-04-22       Impact factor: 4.534

2.  Phosphoglycerate kinase 1 promoting tumor progression and metastasis in gastric cancer - detected in a tumor mouse model using positron emission tomography/magnetic resonance imaging.

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Journal:  Cell Physiol Biochem       Date:  2010-08-24

3.  Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo.

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Journal:  Int J Cancer       Date:  2008-12-15       Impact factor: 7.396

4.  Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis.

Authors:  Rongli Sun; Xing Meng; Yunqiu Pu; Fengxia Sun; Zhaodi Man; Juan Zhang; Lihong Yin; Yuepu Pu
Journal:  Toxicol In Vitro       Date:  2018-11-15       Impact factor: 3.500

5.  Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.

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Journal:  Cancer Cell       Date:  2018-02-15       Impact factor: 31.743

Review 6.  Targeting HIF-1 for cancer therapy.

Authors:  Gregg L Semenza
Journal:  Nat Rev Cancer       Date:  2003-10       Impact factor: 60.716

7.  Metabolic quirks yield tumour hope.

Authors:  Heidi Ledford
Journal:  Nature       Date:  2014-04-10       Impact factor: 69.504

8.  A combined gene signature of hypoxia and notch pathway in human glioblastoma and its prognostic relevance.

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Journal:  PLoS One       Date:  2015-03-03       Impact factor: 3.240

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Authors:  Jianhua Wang; Gigi Ying; Jingchen Wang; Younghun Jung; Jian Lu; Jiang Zhu; Kenneth J Pienta; Russell S Taichman
Journal:  Cancer Res       Date:  2010-01-12       Impact factor: 13.312

10.  Down-Regulated Phosphoglycerate Kinase 1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Cancer.

Authors:  Wei Lu; Jian Gao; Jingyun Yang; Yang Cao; Lin Jiang; Maolan Li; Yijian Zhang; Jian Zhou; Yingbin Liu
Journal:  Medicine (Baltimore)       Date:  2015-12       Impact factor: 1.817
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  34 in total

1.  Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea.

Authors:  Maura Rojas-Pirela; Diego Andrade-Alviárez; Verónica Rojas; Ulrike Kemmerling; Ana J Cáceres; Paul A Michels; Juan Luis Concepción; Wilfredo Quiñones
Journal:  Open Biol       Date:  2020-11-25       Impact factor: 6.411

Review 2.  Glycolysis in the progression of pancreatic cancer.

Authors:  Xinyao Chang; Xingchen Liu; Haoze Wang; Xuan Yang; Yan Gu
Journal:  Am J Cancer Res       Date:  2022-02-15       Impact factor: 6.166

3.  Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1.

Authors:  Tongxin Xu; Zhaoyang Yan; Juntao Lu; Liying Chen; Xiaoxu Li; Yan Li; Zhiming Dong; Wei Guo
Journal:  Clin Exp Metastasis       Date:  2022-06-17       Impact factor: 4.510

Review 4.  Overcoming chemoresistance by targeting reprogrammed metabolism: the Achilles' heel of pancreatic ductal adenocarcinoma.

Authors:  Abudureyimu Tuerhong; Jin Xu; Si Shi; Zhen Tan; Qingcai Meng; Jie Hua; Jiang Liu; Bo Zhang; Wei Wang; Xianjun Yu; Chen Liang
Journal:  Cell Mol Life Sci       Date:  2021-06-15       Impact factor: 9.261

5.  Novel PGK1 determines SKP2-dependent AR stability and reprograms granular cell glucose metabolism facilitating ovulation dysfunction.

Authors:  Xia Liu; Changfa Sun; Kexin Zou; Cheng Li; Xiaojun Chen; Hangchao Gu; Zhiyang Zhou; Zuwei Yang; Yaoyao Tu; Ningxin Qin; Yiran Zhao; Yimei Wu; Yicong Meng; Guolian Ding; Xinmei Liu; Jianzhong Sheng; Chuanjin Yu; Hefeng Huang
Journal:  EBioMedicine       Date:  2020-10-21       Impact factor: 8.143

6.  Genomic Landscape of HCC.

Authors:  Adeniji Nia; Renumathy Dhanasekaran
Journal:  Curr Hepatol Rep       Date:  2020-11-10

7.  Activation of PGK1 under hypoxic conditions promotes glycolysis and increases stem cell‑like properties and the epithelial‑mesenchymal transition in oral squamous cell carcinoma cells via the AKT signalling pathway.

Authors:  Yadong Zhang; Hongshi Cai; Yan Liao; Yue Zhu; Fang Wang; Jinsong Hou
Journal:  Int J Oncol       Date:  2020-06-16       Impact factor: 5.650

8.  Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1.

Authors:  Jean Chiou; Michael Hsiao; Yu-Chan Chang; Ming-Hsien Chan; Chien-Hsiu Li; Chih-Jen Yang; Yu-Wen Tseng; Hsing-Fang Tsai
Journal:  Cell Death Discov       Date:  2021-06-05

9.  Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer.

Authors:  Yanping Li; Shanshan Wang; Xiaoyuan Zhang; Rui Yang; Xiaonan Wei; Ruirong Yan; Yaru Jiang; Wenzhi Shen
Journal:  Front Mol Biosci       Date:  2021-07-05

10.  Long noncoding RNA MSC-AS1 promotes hepatocellular carcinoma oncogenesis via inducing the expression of phosphoglycerate kinase 1.

Authors:  Cong Cao; Qiuhong Zhong; Liuxue Lu; Bin Huang; Jun Li; Lianxin Meng; Hua Wei
Journal:  Cancer Med       Date:  2020-06-02       Impact factor: 4.452
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