| Literature DB >> 34131808 |
Abudureyimu Tuerhong1,2,3,4, Jin Xu1,2,3,4, Si Shi1,2,3,4, Zhen Tan1,2,3,4, Qingcai Meng1,2,3,4, Jie Hua1,2,3,4, Jiang Liu1,2,3,4, Bo Zhang1,2,3,4, Wei Wang1,2,3,4, Xianjun Yu5,6,7,8, Chen Liang9,10,11,12.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death due to its late diagnosis that removes the opportunity for surgery and metabolic plasticity that leads to resistance to chemotherapy. Metabolic reprogramming related to glucose, lipid, and amino acid metabolism in PDAC not only enables the cancer to thrive and survive under hypovascular, nutrient-poor and hypoxic microenvironments, but also confers chemoresistance, which contributes to the poor prognosis of PDAC. In this review, we systematically elucidate the mechanism of chemotherapy resistance and the relationship of metabolic programming features with resistance to anticancer drugs in PDAC. Targeting the critical enzymes and/or transporters involved in glucose, lipid, and amino acid metabolism may be a promising approach to overcome chemoresistance in PDAC. Consequently, regulating metabolism could be used as a strategy against PDAC and could improve the prognosis of PDAC.Entities:
Keywords: Chemotherapy; Glutamine; Glycolysis; Lipogenesis; Pancreatic cancer
Year: 2021 PMID： 34131808 DOI： 10.1007/s00018-021-03866-y
Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261