| Literature DB >> 29455928 |
Ling Li1, Yingchun Liang1, Lei Kang2, Yang Liu3, Shan Gao4, Siyu Chen3, Ying Li5, Wenye You5, Qian Dong1, Tian Hong1, Zhifeng Yan6, Shuai Jin3, Tao Wang7, Wei Zhao8, Haixing Mai9, Jun Huang9, Xiao Han1, Quanbo Ji10, Qi Song11, Chao Yang8, Shixin Zhao1, Xiaojie Xu12, Qinong Ye13.
Abstract
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target.Entities:
Keywords: SIX1; Warburg effect; aerobic glycolysis; cancer; microRNA; transcription factor
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Year: 2018 PMID： 29455928 DOI： 10.1016/j.ccell.2018.01.010
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743