Literature DB >> 31802094

A hybrid polymer to target blood group dependence of cholera toxin.

Diksha Haksar1, Linda Quarles van Ufford, Roland J Pieters.   

Abstract

Cholera is a potentially fatal bacterial infection caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. GM1 has long been known as the receptor of the cholera toxin in the intestine. However, increasing evidence is pointing towards the role of fucosylated conjugates as additional attachment options of the toxin. In the present paper we have synthesized a polymeric hybrid which can inhibit both modes of attachment.

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Year:  2019        PMID： 31802094     DOI： 10.1039/c9ob02369k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Fighting Shigella by Blocking Its Disease-Causing Toxin.

Authors:  Diksha Haksar; Mostafa Asadpoor; Torben Heise; Jie Shi; Saskia Braber; Gert Folkerts; Lluis Ballell; Janneth Rodrigues; Roland J Pieters
Journal:  J Med Chem       Date:  2021-04-28       Impact factor: 7.446

Review 2.  Anti-Pathogenic Functions of Non-Digestible Oligosaccharides In Vitro.

Authors:  Mostafa Asadpoor; Casper Peeters; Paul A J Henricks; Soheil Varasteh; Roland J Pieters; Gert Folkerts; Saskia Braber
Journal:  Nutrients       Date:  2020-06-16       Impact factor: 5.717

3.  Fucose-Galactose Polymers Inhibit Cholera Toxin Binding to Fucosylated Structures and Galactose-Dependent Intoxication of Human Enteroids.

Authors:  Jakob Cervin; Andrew Boucher; Gyusaang Youn; Per Björklund; Ville Wallenius; Lynda Mottram; Nicole S Sampson; Ulf Yrlid
Journal:  ACS Infect Dis       Date:  2020-03-19       Impact factor: 5.084

Review 4.  Non-Digestible Oligosaccharides and Short Chain Fatty Acids as Therapeutic Targets against Enterotoxin-Producing Bacteria and Their Toxins.

Authors:  Mostafa Asadpoor; Georgia-Nefeli Ithakisiou; Paul A J Henricks; Roland Pieters; Gert Folkerts; Saskia Braber
Journal:  Toxins (Basel)       Date:  2021-02-25       Impact factor: 4.546

5.  Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.

Authors:  Ryan McBerney; Jonathan P Dolan; Emma E Cawood; Michael E Webb; W Bruce Turnbull
Journal:  JACS Au       Date:  2022-08-26

6.  Targeting Multiple Binding Sites on Cholera Toxin B with Glycomimetic Polymers Promotes the Formation of Protein-Polymer Aggregates.

Authors:  Gyusaang Youn; Jakob Cervin; Xiaoxi Yu; Surita R Bhatia; Ulf Yrlid; Nicole S Sampson
Journal:  Biomacromolecules       Date:  2020-10-05       Impact factor: 6.988
  6 in total

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