Julia M Stauber1, Elaine A Qian1,2,3, Yanxiao Han4, Arnold L Rheingold5, Petr Král4,6,7, Daishi Fujita8, Alexander M Spokoyny1,3. 1. Department of Chemistry and Biochemistry , University of California, Los Angeles , Los Angeles , California 90095 , United States. 2. Department of Bioengineering , University of California, Los Angeles , Los Angeles , California 90095 , United States. 3. California NanoSystems Institute , University of California, Los Angeles , Los Angeles , California 90095 , United States. 4. Department of Chemistry , University of Illinois at Chicago , Chicago , Illinois 60607 , United States. 5. Department of Chemistry and Biochemistry , University of California, San Diego , La Jolla , California 92093 , United States. 6. Department of Physics , University of Illinois at Chicago , Chicago , Illinois 60607 , United States. 7. Department of Biopharmaceutical Sciences , University of Illinois at Chicago , Chicago , Illinois 60612 , United States. 8. Institute for Integrated Cell-Material Sciences , Kyoto University , Kyoto 606-8302 , Japan.
Abstract
For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.
For decades, chemists have strived to mimic the intricate design and diverse functions of naturally occurring systems through the bioinspired synthesis of programmable inorganic nanomaterials. The development of thiol-capped gold nanoparticles (n class="Chemical">AuNPs) has driven advancement in this area; however, although versatile and readily accessible, hybrid AuNPs are rarely atomically precise, which limits control over their surface topology and therefore the study of complex structure-function relationships. Here, we present a bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies. For the first time, using a structurally characterized cluster-based organometallic building block, we demonstrate the systematic synthesis of nanoclusters with multivalent binding capabilities to complex protein targets.
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