Literature DB >> 35006969

Amphiphilic DTPA Multimer Assembled on Icosahedral Closo-Borane Motif as High-Performance MRI Blood Pool Contrast Agent.

Lalit N Goswami1, Shatadru Chakravarty1,2,3, Quan-Yu Cai1,4, Erik M Shapiro2,3, M Frederick Hawthorne1, Lixin Ma1,4.   

Abstract

A multimeric MRI blood pool contrast agent based on the closo-borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized closo-borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement in vitro and in vivo.

Entities:  

Keywords:  blood pool contrast agent; borane closomer; human serum albumin binding; magnetic resonance angiography; vasculature imaging

Mesh：

Substances：

Year:  2021        PMID： 35006969      PMCID： PMC8793076          DOI： 10.1021/acsabm.1c00717

Source DB:  PubMed          Journal:  ACS Appl Bio Mater        ISSN： 2576-6422


  26 in total

1.  Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action.

Authors:  Peter Caravan
Journal:  Acc Chem Res       Date:  2009-07-21       Impact factor: 22.384

Review 2.  From fundamental supramolecular chemistry to self-assembled nanomaterials and medicines and back again - how Sam inspired SAMul.

Authors:  David K Smith
Journal:  Chem Commun (Camb)       Date:  2018-05-08       Impact factor: 6.222

3.  A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery.

Authors:  Shatadru Chakravarty; Saurav J Sarma; Lalit N Goswami; Quan-Yu Cai; Erik M Shapiro; M Frederick Hawthorne; Lixin Ma
Journal:  Chem Commun (Camb)       Date:  2019-10-10       Impact factor: 6.222

Review 4.  Applications of nanoparticles in biomedical imaging.

Authors:  Xiangjun Han; Ke Xu; Olena Taratula; Khashayar Farsad
Journal:  Nanoscale       Date:  2019-01-17       Impact factor: 7.790

Review 5.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

6.  A Manganese-based Alternative to Gadolinium: Contrast-enhanced MR Angiography, Excretion, Pharmacokinetics, and Metabolism.

Authors:  Eric M Gale; Hsiao-Ying Wey; Ian Ramsay; Yi-Fen Yen; David E Sosnovik; Peter Caravan
Journal:  Radiology       Date:  2017-11-08       Impact factor: 11.105

Review 7.  Biodistribution of gadolinium-based contrast agents, including gadolinium deposition.

Authors:  Silvio Aime; Peter Caravan
Journal:  J Magn Reson Imaging       Date:  2009-12       Impact factor: 4.813

8.  Discrete nanomolecular polyhedral borane scaffold supporting multiple gadolinium(III) complexes as a high performance MRI contrast agent.

Authors:  Lalit N Goswami; Lixin Ma; Shatadru Chakravarty; Quanyu Cai; Satish S Jalisatgi; M Frederick Hawthorne
Journal:  Inorg Chem       Date:  2012-11-05       Impact factor: 5.165

9.  Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent.

Authors:  Peter Caravan; Giacomo Parigi; Jaclyn M Chasse; Normand J Cloutier; Jeffrey J Ellison; Randall B Lauffer; Claudio Luchinat; Sarah A McDermid; Marga Spiller; Thomas J McMurry
Journal:  Inorg Chem       Date:  2007-07-11       Impact factor: 5.165

Review 10.  Abdominal aortic aneurysms.

Authors:  Natzi Sakalihasan; Jean-Baptiste Michel; Athanasios Katsargyris; Helena Kuivaniemi; Jean-Olivier Defraigne; Alain Nchimi; Janet T Powell; Koichi Yoshimura; Rebecka Hultgren
Journal:  Nat Rev Dis Primers       Date:  2018-10-18       Impact factor: 52.329
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