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Literature DB >> 31782507

Metabolomics Signatures in Type 2 Diabetes: A Systematic Review and Integrative Analysis.

Yue Sun^1,2, Hao-Yu Gao¹, Zhi-Yuan Fan¹, Yan He^1,2, Yu-Xiang Yan^1,2.

Abstract

OBJECTIVE: Metabolic signatures have emerged as valuable signaling molecules in the biochemical process of type 2 diabetes (T2D). To summarize and identify metabolic biomarkers in T2D, we performed a systematic review and meta-analysis of the associations between metabolites and T2D using high-throughput metabolomics techniques.
METHODS: We searched relevant studies from MEDLINE (PubMed), Embase, Web of Science, and Cochrane Library as well as Chinese databases (Wanfang, Vip, and CNKI) inception through 31 December 2018. Meta-analysis was conducted using STATA 14.0 under random effect. Besides, bioinformatic analysis was performed to explore molecule mechanism by MetaboAnalyst and R 3.5.2.
RESULTS: Finally, 46 articles were included in this review on metabolites involved amino acids, acylcarnitines, lipids, carbohydrates, organic acids, and others. Results of meta-analysis in prospective studies indicated that isoleucine, leucine, valine, tyrosine, phenylalanine, glutamate, alanine, valerylcarnitine (C5), palmitoylcarnitine (C16), palmitic acid, and linoleic acid were associated with higher T2D risk. Conversely, serine, glutamine, and lysophosphatidylcholine C18:2 decreased risk of T2D. Arginine and glycine increased risk of T2D in the Western countries subgroup, and betaine was negatively correlated with T2D in nested case-control subgroup. In addition, slight improvements in T2D prediction beyond traditional risk factors were observed when adding these metabolites in predictive analysis. Pathway analysis identified 17 metabolic pathways may alter in the process of T2D and metabolite-related genes were also enriched in functions and pathways associated with T2D.
CONCLUSIONS: Several metabolites and metabolic pathways associated with T2D have been identified, which provide valuable biomarkers and novel targets for prevention and drug therapy. © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities: Chemical Disease Gene

Keywords: Biomarkers; Metabolomics; Prediction; Type 2 diabetes

Year: 2020 PMID： 31782507 DOI： 10.1210/clinem/dgz240

Source DB: PubMed Journal: J Clin Endocrinol Metab ISSN： 0021-972X Impact factor: 5.958

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Cited

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Metabolomics Signatures in Type 2 Diabetes: A Systematic Review and Integrative Analysis.

1. Novel Plasma Metabolomic Markers Associated with Diabetes Progression in Older Puerto Ricans.

2. Investigation into potential mechanisms of metabolic syndrome by integrative analysis of metabolomics and proteomics.

3. Magnetic field therapy enhances muscle mitochondrial bioenergetics and attenuates systemic ceramide levels following ACL reconstruction: Southeast Asian randomized-controlled pilot trial.

4. Serum Metabolomics of Incident Diabetes and Glycemic Changes in a Population With High Diabetes Burden: The Hispanic Community Health Study/Study of Latinos.

5. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.

6. Circulating metabolites and lipids are associated with glycaemic measures in South Asians.

7. Metabolomics in Glaucoma: A Systematic Review.

8. Metabolomics in Age-Related Macular Degeneration: A Systematic Review.

9. Amino Acid Signature of Oxidative Stress in Patients with Type 2 Diabetes: Targeted Exploratory Metabolomic Research.

Review 10. A Scoping Review: Metabolomics Signatures Associated with Animal and Plant Protein Intake and Their Potential Relation with Cardiometabolic Risk.