Jesintha Navaratnam1,2, Thomas P Bærland1, Nils A Eide1, Rowan T Faber1, Bernt L Rekstad3, Demetrios G Vavvas4, Ragnheiður Bragadóttir1,2. 1. Department of Ophthalmology, Oslo University Hospital, Oslo, Norway. 2. University of Oslo, Oslo, Norway. 3. Department of Medical Physics, Oslo University Hospital, Oslo, Norway. 4. Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
Abstract
BACKGROUND: Early confirmation of the effect of brachytherapy for choroidal melanoma showing that tumour coverage is valuable. The irradiated retinal pigment epithelium (RPE) commonly develops atrophy. This study compares the fundus autofluorescence (AF) changes to the development of RPE atrophy following brachytherapy. METHODS: Retrospective study of 19 patients treated with <sup>106</sup>Ru and 2 with <sup>125</sup>I plaques with either a 3- or 6-month follow-up period. Ultra-widefield (UW) composite colour and AF images were obtained with Optomap 200Tx and interpreted as complete, partial, or no RPE changes and complete or partial hyperautofluorescence, hypoautofluorescence, or isoautofluorescence. RESULTS: At the 3-month follow-up, 9 of 13 patients (69%) (95% confidence interval [CI], 0.389-0.896) treated with <sup>106</sup>Ru plaques developed complete homogenous hyperautofluorescence surrounding the tumour, but only 1 of 13 (8%) (95% CI, 0.004-0.379) developed complete RPE atrophy at the same time point. Six patients in the <sup>106</sup>Ru plaque group had their first follow-up with UW imaging at 6 months. Four of them developed homogenous hyperautofluorescence and none developed complete RPE atrophy around the tumour. The 2 patients treated with <sup>125</sup>I did not demonstrate any clear RPE or AF changes. CONCLUSION: The effect of <sup>106</sup>Ru plaque treatment on fundus UW imaging is detected as homogenous and well-demarcated hyperautofluorescence before visible RPE atrophy.
BACKGROUND: Early confirmation of the effect of brachytherapy for choroidal melanoma showing that tumour coverage is valuable. The irradiated retinal pigment epithelium (RPE) commonly develops atrophy. This study compares the fundus autofluorescence (AF) changes to the development of RPE atrophy following brachytherapy. METHODS: Retrospective study of 19 patients treated with <sup>106</sup>Ru and 2 with <sup>125</sup>I plaques with either a 3- or 6-month follow-up period. Ultra-widefield (UW) composite colour and AF images were obtained with Optomap 200Tx and interpreted as complete, partial, or no RPE changes and complete or partial hyperautofluorescence, hypoautofluorescence, or isoautofluorescence. RESULTS: At the 3-month follow-up, 9 of 13 patients (69%) (95% confidence interval [CI], 0.389-0.896) treated with <sup>106</sup>Ru plaques developed complete homogenous hyperautofluorescence surrounding the tumour, but only 1 of 13 (8%) (95% CI, 0.004-0.379) developed complete RPE atrophy at the same time point. Six patients in the <sup>106</sup>Ru plaque group had their first follow-up with UW imaging at 6 months. Four of them developed homogenous hyperautofluorescence and none developed complete RPE atrophy around the tumour. The 2 patients treated with <sup>125</sup>I did not demonstrate any clear RPE or AF changes. CONCLUSION: The effect of <sup>106</sup>Ru plaque treatment on fundus UW imaging is detected as homogenous and well-demarcated hyperautofluorescence before visible RPE atrophy.
Authors: Carol L Shields; Minoru Furuta; Arman Mashayekhi; Edwina L Berman; Jonathan D Zahler; Daniel M Hoberman; Diep H Dinh; Jerry A Shields Journal: Ophthalmology Date: 2007-12-11 Impact factor: 12.079
Authors: Almut Bindewald-Wittich; Frank G Holz; Thomas Ach; Miltiadis Fiorentzis; Nikolaos E Bechrakis; Gregor D Willerding Journal: Cancers (Basel) Date: 2022-04-02 Impact factor: 6.639