PURPOSE: To describe the clinical features and natural course of choroidal nevi with retinal pigment epithelial (RPE) trough. METHODS: Retrospective observational case series. RESULTS: Of the 90 patients (91 choroidal nevi), 88 (98%) were Caucasian and 59 (66%) were women, with a mean age of 56 years (range 18-79 years) at presentation. The mean largest nevus basal diameter was 7 mm (range 3-12 mm) and the mean thickness was 2.2 mm (range 0.8-3.4 mm). Orange pigment and subretinal fluid were associated with 9 (10%) and 16 (18%) of the nevi, respectively. Overlying RPE alterations included RPE atrophy (93%), RPE hyperplasia (74%), drusen (54%), and RPE fibrous metaplasia (36%). Retinal pigment epithelial trough was present at initial evaluation in 88 eyes and developed during follow-up from a long-standing pocket of shallow subretinal fluid in 3 other eyes. The mean largest dimension of the RPE trough was 4 mm (range 1-16 mm) and most (76%) were located at the inferior margin of the nevus. Of 91 nevi, 82 had subsequent follow-up with a mean follow-up duration of 79 months (range 3-464 mo). Of these, 19 (23%) showed slight growth and only 3 (4%) had presumed transformation into melanoma. None of the patients showed evidence of distant metastasis. CONCLUSIONS: Retinal pigment epithelial trough results from resorption of long-standing serous subretinal fluid and should therefore be considered a sign of chronicity of choroidal nevi. Choroidal nevi associated with RPE trough, despite their greater thickness and larger size, are relatively stable with minimal risk of progression into melanoma.
PURPOSE: To describe the clinical features and natural course of choroidal nevi with retinal pigment epithelial (RPE) trough. METHODS: Retrospective observational case series. RESULTS: Of the 90 patients (91 choroidal nevi), 88 (98%) were Caucasian and 59 (66%) were women, with a mean age of 56 years (range 18-79 years) at presentation. The mean largest nevus basal diameter was 7 mm (range 3-12 mm) and the mean thickness was 2.2 mm (range 0.8-3.4 mm). Orange pigment and subretinal fluid were associated with 9 (10%) and 16 (18%) of the nevi, respectively. Overlying RPE alterations included RPE atrophy (93%), RPE hyperplasia (74%), drusen (54%), and RPE fibrous metaplasia (36%). Retinal pigment epithelial trough was present at initial evaluation in 88 eyes and developed during follow-up from a long-standing pocket of shallow subretinal fluid in 3 other eyes. The mean largest dimension of the RPE trough was 4 mm (range 1-16 mm) and most (76%) were located at the inferior margin of the nevus. Of 91 nevi, 82 had subsequent follow-up with a mean follow-up duration of 79 months (range 3-464 mo). Of these, 19 (23%) showed slight growth and only 3 (4%) had presumed transformation into melanoma. None of the patients showed evidence of distant metastasis. CONCLUSIONS:Retinal pigment epithelial trough results from resorption of long-standing serous subretinal fluid and should therefore be considered a sign of chronicity of choroidal nevi. Choroidal nevi associated with RPE trough, despite their greater thickness and larger size, are relatively stable with minimal risk of progression into melanoma.
Authors: Fredy Geiger; Sadiq Said; Anahita Bajka; Mario Damiano Toro; Maximilian Robert Justus Wiest; Marc Stahel; Daniel Barthelmes; Sandrine Anne Zweifel Journal: Curr Oncol Date: 2022-02-11 Impact factor: 3.677
Authors: Jesintha Navaratnam; Thomas P Bærland; Nils A Eide; Rowan T Faber; Bernt L Rekstad; Demetrios G Vavvas; Ragnheiður Bragadóttir Journal: Ocul Oncol Pathol Date: 2019-05-16