Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity.

This review focuses on the biomedical applications and toxicity of spinel ferrite nanoparticles (SFNPs) with more emphasis on the recently published work. A critical review is provided on recent advances of SFNPs applications in biomedical areas. The novelty of SFNPs in addressing the bottleneck problems encountered in the areas of health; in particular, for diagnosis and treatment of tumour cells are well reviewed. Furthermore, research gaps, toxicity of SFNPs and areas which still need more attention are highlighted. Based on the result of this review, the SFNPs have unlimited capacity in cancer treatment, disease diagnosis, magnetic resonance imaging, drug delivery and release. Overall, stepping out of the conventional way of treatment is difficult but also essential in bringing long lasting solution for cancer and other diseases treatment. In fact, the toxicity study and commercialisation of the SFNPs based cancer treatment options are the main challenges and need further study, in order to reduce unforeseen consequences.