Ana Isabel Moreira1, Luzia Mendes2, José António Pereira2. 1. Faculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal. up201405245@fmd.up.pt. 2. Faculty of Dental Medicine of University of Porto, Rua Dr. Manuel Pereira da Silva, 4200-393, Porto, Portugal.
Abstract
PURPOSE: To re-assess the scientific literature to ascertain if there is scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections. INTRODUCTION: Prosthetic joint infections occur in approximately 0.3-2% of patients and, of these, around 6-13% are thought to be caused by oral bacteria. Antibiotic prophylaxis prior to dental procedures as a means to prevent a prosthetic joint infection has been controversial throughout the years. However, it remains unclear to what extent it has a beneficial effect. We do know that bacteraemia of oral origin is directly proportional to any ongoing inflammation or infection, and that a diseased periodontium may act as an entry for bacteria to spread to distant locations, through the bloodstream, and potentially be the cause of distant site infections. MATERIALS AND METHODS: Updated literature search using the PubMed (Medline), and the Clarivate Analytics databases, to identify eligible articles since the previous searches up to April 2019 (last 5 years). RESULTS: No studies that relate periodontal disease to the development of a prosthetic joint infection were found. CONCLUSION: Currently, there is no evidence to support or exclude the need of antibiotic prophylaxis as a means to decrease the risk of prosthetic joint infections in patients with periodontal disease.
PURPOSE: To re-assess the scientific literature to ascertain if there is scientific evidence to support antibiotic prophylaxis in patients with periodontal disease as a means to decrease the risk of prosthetic joint infections. INTRODUCTION: Prosthetic joint infections occur in approximately 0.3-2% of patients and, of these, around 6-13% are thought to be caused by oral bacteria. Antibiotic prophylaxis prior to dental procedures as a means to prevent a prosthetic joint infection has been controversial throughout the years. However, it remains unclear to what extent it has a beneficial effect. We do know that bacteraemia of oral origin is directly proportional to any ongoing inflammation or infection, and that a diseased periodontium may act as an entry for bacteria to spread to distant locations, through the bloodstream, and potentially be the cause of distant site infections. MATERIALS AND METHODS: Updated literature search using the PubMed (Medline), and the Clarivate Analytics databases, to identify eligible articles since the previous searches up to April 2019 (last 5 years). RESULTS: No studies that relate periodontal disease to the development of a prosthetic joint infection were found. CONCLUSION: Currently, there is no evidence to support or exclude the need of antibiotic prophylaxis as a means to decrease the risk of prosthetic joint infections in patients with periodontal disease.
Authors: Elie F Berbari; Douglas R Osmon; Alan Carr; Arlen D Hanssen; Larry M Baddour; Doris Greene; Leo I Kupp; Linda W Baughan; W Scott Harmsen; Jayawant N Mandrekar; Terry M Therneau; James M Steckelberg; Abinash Virk; Walter R Wilson Journal: Clin Infect Dis Date: 2010-01-01 Impact factor: 9.079
Authors: Willem M H Rademacher; Geert H I M Walenkamp; Dirk Jan F Moojen; Johannes G E Hendriks; Theo A Goedendorp; Frederik R Rozema Journal: Acta Orthop Date: 2017-06-22 Impact factor: 3.717
Authors: Gerhard Schmalz; Laura Schmidt; Rainer Haak; Stefan Büchi; Szymon Goralski; Andreas Roth; Dirk Ziebolz Journal: J Clin Med Date: 2022-04-29 Impact factor: 4.241