OBJECTIVE: Fusobacterium nucleatum is an anaerobic gram-negative bacilli that is one of the oral and other mucosal surface microbiota. It involves a wide range of human diseases and was first found in periodontal diseases, but reports of bone-related infections caused by F. nucleatum are rare, especially periprosthetic joint infections (PJI). METHODS: Here, we present the first case of acute hematogenous PJI of the hip joint caused by F. nucleatum, and debridement, antibiotics, and implant retention (DAIR) was performed. RESULTS: The patient was successfully treated with DAIR, identification of isolates by metagenomics next-generation sequencing was confirmed by polymerase chain reaction. CONCLUSIONS: For stable acute hematogenous PJI after hip replacement, quick and accurate diagnosis, the identification of pathogenic microorganisms, and the use of DAIR combined with sufficient sensitive antibiotics have a certain clinical effect and can achieve the purpose of both preserving the prosthesis and infection control.
OBJECTIVE:Fusobacterium nucleatum is an anaerobic gram-negative bacilli that is one of the oral and other mucosal surface microbiota. It involves a wide range of human diseases and was first found in periodontal diseases, but reports of bone-related infections caused by F. nucleatum are rare, especially periprosthetic joint infections (PJI). METHODS: Here, we present the first case of acute hematogenous PJI of the hip joint caused by F. nucleatum, and debridement, antibiotics, and implant retention (DAIR) was performed. RESULTS: The patient was successfully treated with DAIR, identification of isolates by metagenomics next-generation sequencing was confirmed by polymerase chain reaction. CONCLUSIONS: For stable acute hematogenous PJI after hip replacement, quick and accurate diagnosis, the identification of pathogenic microorganisms, and the use of DAIR combined with sufficient sensitive antibiotics have a certain clinical effect and can achieve the purpose of both preserving the prosthesis and infection control.
Authors: Andrej Trampuz; Kerryl E Piper; Melissa J Jacobson; Arlen D Hanssen; Krishnan K Unni; Douglas R Osmon; Jayawant N Mandrekar; Franklin R Cockerill; James M Steckelberg; James F Greenleaf; Robin Patel Journal: N Engl J Med Date: 2007-08-16 Impact factor: 91.245
Authors: Morgan I Ivy; Matthew J Thoendel; Patricio R Jeraldo; Kerryl E Greenwood-Quaintance; Arlen D Hanssen; Matthew P Abdel; Nicholas Chia; Janet Z Yao; Aaron J Tande; Jayawant N Mandrekar; Robin Patel Journal: J Clin Microbiol Date: 2018-08-27 Impact factor: 5.948
Authors: J C Rodríguez Duque; P Galindo Rubín; B González Humara; A A Quesada Sanz; M B Busta Vallina; M Fernández-Sampedro Journal: Anaerobe Date: 2018-08-16 Impact factor: 3.331
Authors: Charles Cazanave; Kerryl E Greenwood-Quaintance; Arlen D Hanssen; Melissa J Karau; Suzannah M Schmidt; Eric O Gomez Urena; Jayawant N Mandrekar; Douglas R Osmon; Lindsay E Lough; Bobbi S Pritt; James M Steckelberg; Robin Patel Journal: J Clin Microbiol Date: 2013-05-08 Impact factor: 5.948