Hector M González1, Wassim Tarraf2, Neil Schneiderman3, Myriam Fornage4, Priscilla M Vásquez5, Donglin Zeng6, Marston Youngblood6, Linda C Gallo7, Martha L Daviglus8, Richard B Lipton9, Robert Kaplan10, Alberto R Ramos11, Melissa Lamar12, Sonia Thomas13, Albert Chai5, Charles DeCarli14. 1. Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA. Electronic address: hectorgonzalez@ucsd.edu. 2. Department of Healthcare Sciences, Wayne State University, Institute of Gerontology, Detroit, MI, USA. 3. Department of Psychology, University of Miami, Miami, FL, USA. 4. University of Texas Health Science Center, Houston, TX, USA. 5. Department of Neurosciences, Shiley-Marcos Alzheimer's Disease Research Center, UC San Diego, San Diego, CA, USA. 6. Department of Biostatistics, University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA. 7. Department of Psychology, San Diego State University, San Diego, CA, USA. 8. Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA. 9. Albert Einstein, College of Medicine, New York, NY, USA. 10. Albert Einstein, College of Medicine, New York, NY, USA; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle WA, USA. 11. Department of Neurology, University of Miami, Miami, FL, USA. 12. Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA; Department of Psychiatry and Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. 13. RTI International, Research Triangle Park, NC, USA. 14. Department of Neurology, Alzheimer's Disease Center, UC Davis, Sacramento, CA, USA.
Abstract
INTRODUCTION: We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos. METHODS: Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer's Association diagnostic criteria. RESULTS: The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI. DISCUSSION: MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
INTRODUCTION: We estimated the prevalence and correlates of mild cognitive impairment (MCI) among middle-aged and older diverse Hispanics/Latinos. METHODS: Middle-aged and older diverse Hispanics/Latinos enrolled (n = 6377; 50-86 years) in this multisite prospective cohort study were evaluated for MCI using the National Institute on Aging-Alzheimer's Association diagnostic criteria. RESULTS: The overall MCI prevalence was 9.8%, which varied between Hispanic/Latino groups. Older age, high cardiovascular disease (CVD) risk, and elevated depressive symptoms were significant correlates of MCI prevalence. Apolipoprotein E4 (APOE) and APOE2 were not significantly associated with MCI. DISCUSSION: MCI prevalence varied among Hispanic/Latino backgrounds, but not as widely as reported in the previous studies. CVD risk and depressive symptoms were associated with increased MCI, whereas APOE4 was not, suggesting alternative etiologies for MCI among diverse Hispanics/Latinos. Our findings suggest that mitigating CVD risk factors may offer important pathways to understanding and reducing MCI and possibly dementia among diverse Hispanics/Latinos.
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