Sid E O'Bryant1, Robert C Barber2, Nicole Philips2, Leigh A Johnson1,2, James R Hall1, Kumudu Subasinghe2, Melissa Petersen1,3, Arthur W Toga4, Kristine Yaffe5,6, Robert A Rissman7,8. 1. Institute for Translational Research, University of North Texas Health Science Center, Fort Worth, Texas, USA. 2. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA. 3. Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, Texas, USA. 4. Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Las Angeles, California, USA. 5. Department of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California, San Francisco, California, USA. 6. San Francisco VA Medical Center, San Francisco, California, USA. 7. Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. 8. Veterans Affairs San Diego Healthcare System, San Diego, California, USA.
Abstract
INTRODUCTION: The APOEε4 allele is the single strongest genetic risk for late-onset Alzheimer's disease (AD). Prior work demonstrates that not only the APOEε4 allele varies by race/ethnicity but also the risk for AD and cognitive impairment conveyed by the APOEε4 allele varies by the racial/ethnic group as well as genetic ancestry. Here, we sought to examine the link between the APOEε4 and neuropsychological functioning among Mexican Americans (MAs). METHODS: Data were examined from 1,633 (852 MAs and 781 non-Hispanic Whites [NHWs]) participants of the Health & Aging Brain Study - Health Disparities (HABS-HD) and were enrolled with all requisite data to be included into the current analyses. RESULTS: The frequency of both ε4 and ε2 alleles was significantly lower among MAs as compared to NHWs. Among MAs, APOEε4 allele presence was associated specifically with poorer immediate and delayed memory (Wechsler Memory Scale - Third Edition [WMS-III] Logical Memory and Spanish-English Verbal Learning Test [SEVLT]). Among NHWs, APOEε4 allele presence was associated with poorer immediate and delayed memory as well as worse executive functioning (Trials B) and verbal fluency (Animal naming). DISCUSSION/ CONCLUSION: The APOEε4 allele was associated with poorer cognition across multiple domains among NHWs; however, allele presence was specifically associated with poorer memory performance among MAs. When combined with prior work, the current findings demonstrate that the risk factors associated with cognitive dysfunction differ among MAs as compared to NHWs and require additional investigation.
INTRODUCTION: The APOEε4 allele is the single strongest genetic risk for late-onset Alzheimer's disease (AD). Prior work demonstrates that not only the APOEε4 allele varies by race/ethnicity but also the risk for AD and cognitive impairment conveyed by the APOEε4 allele varies by the racial/ethnic group as well as genetic ancestry. Here, we sought to examine the link between the APOEε4 and neuropsychological functioning among Mexican Americans (MAs). METHODS: Data were examined from 1,633 (852 MAs and 781 non-Hispanic Whites [NHWs]) participants of the Health & Aging Brain Study - Health Disparities (HABS-HD) and were enrolled with all requisite data to be included into the current analyses. RESULTS: The frequency of both ε4 and ε2 alleles was significantly lower among MAs as compared to NHWs. Among MAs, APOEε4 allele presence was associated specifically with poorer immediate and delayed memory (Wechsler Memory Scale - Third Edition [WMS-III] Logical Memory and Spanish-English Verbal Learning Test [SEVLT]). Among NHWs, APOEε4 allele presence was associated with poorer immediate and delayed memory as well as worse executive functioning (Trials B) and verbal fluency (Animal naming). DISCUSSION/ CONCLUSION: The APOEε4 allele was associated with poorer cognition across multiple domains among NHWs; however, allele presence was specifically associated with poorer memory performance among MAs. When combined with prior work, the current findings demonstrate that the risk factors associated with cognitive dysfunction differ among MAs as compared to NHWs and require additional investigation.
Authors: R C Petersen; P S Aisen; L A Beckett; M C Donohue; A C Gamst; D J Harvey; C R Jack; W J Jagust; L M Shaw; A W Toga; J Q Trojanowski; M W Weiner Journal: Neurology Date: 2009-12-30 Impact factor: 9.910
Authors: Hector M González; Wassim Tarraf; Neil Schneiderman; Myriam Fornage; Priscilla M Vásquez; Donglin Zeng; Marston Youngblood; Linda C Gallo; Martha L Daviglus; Richard B Lipton; Robert Kaplan; Alberto R Ramos; Melissa Lamar; Sonia Thomas; Albert Chai; Charles DeCarli Journal: Alzheimers Dement Date: 2019-11-18 Impact factor: 21.566
Authors: Sid E O'Bryant; Leigh Johnson; Joan Reisch; Melissa Edwards; James Hall; Robert Barber; Michael D Devous; Donald Royall; Meharvan Singh Journal: Alzheimers Dement Date: 2013-05-02 Impact factor: 21.566
Authors: Kevin A Matthews; Wei Xu; Anne H Gaglioti; James B Holt; Janet B Croft; Dominic Mack; Lisa C McGuire Journal: Alzheimers Dement Date: 2018-09-19 Impact factor: 21.566
Authors: Sid E O'Bryant; Leigh A Johnson; Robert C Barber; Meredith N Braskie; Bradley Christian; James R Hall; Nalini Hazra; Kevin King; Deydeep Kothapalli; Stephanie Large; David Mason; Elizabeth Matsiyevskiy; Roderick McColl; Rajesh Nandy; Raymond Palmer; Melissa Petersen; Nicole Philips; Robert A Rissman; Yonggang Shi; Arthur W Toga; Raul Vintimilla; Rocky Vig; Fan Zhang; Kristine Yaffe Journal: Alzheimers Dement (Amst) Date: 2021-06-21