P Janhavi1,2, S Divyashree1, K P Sanjailal3, S P Muthukumar1,2. 1. Department of Biochemistry, CSIR Central Food Technological Research Institute, Mysore, India. 2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. 3. Central Instrument Facility Services, CSIR Central Food Technological Research Institute, Mysore, India.
Abstract
CONTEXT: The scientists as well as pharmacologists frequently convert the dose of drugs or extracts between human and different animal species. According to the literature, the extrapolation of the dose by simple conversion based only on body weight is not an accurate method. The miscalculation of dosage conversion may result in adverse effects due to overdose or reduced potency due to underdose. AIM: To develop a conversion calculator with factual factor like Km factor. METHOD: The virtual calculator was developed as a web-based application using hypertext pre-processor programming language. My SQL software was used to store the data related to DoseCal. RESULTS: Based on the Km factor, dose conversion calculator called DoseCal was developed. The DoseCal would provide the dosage for both per kg and actual weight of the animal taken for the experiment. CONCLUSION: The DoseCal would assist scientists in the dosage conversion easily and accurately between species.
CONTEXT: The scientists as well as pharmacologists frequently convert the dose of drugs or extracts between human and different animal species. According to the literature, the extrapolation of the dose by simple conversion based only on body weight is not an accurate method. The miscalculation of dosage conversion may result in adverse effects due to overdose or reduced potency due to underdose. AIM: To develop a conversion calculator with factual factor like Km factor. METHOD: The virtual calculator was developed as a web-based application using hypertext pre-processor programming language. My SQL software was used to store the data related to DoseCal. RESULTS: Based on the Km factor, dose conversion calculator called DoseCal was developed. The DoseCal would provide the dosage for both per kg and actual weight of the animal taken for the experiment. CONCLUSION: The DoseCal would assist scientists in the dosage conversion easily and accurately between species.
Entities:
Keywords:
Dosage conversion; Km factor; animal dose; body surface area; calculator; dose conversion calculator; human dose
Authors: Samantha A Michaels; Matthew A Hulverson; Grant R Whitman; Linh T Tran; Ryan Choi; Erkang Fan; Case W McNamara; Melissa S Love; Kayode K Ojo Journal: Antimicrob Agents Chemother Date: 2022-06-15 Impact factor: 5.938