| Literature DB >> 31723001 |
Vivek L Patel1, Evan L Busch2,3, Tara M Friebel2,4, Angel Cronin4, Goska Leslie5, Lesley McGuffog5, Julian Adlard6, Simona Agata7, Bjarni A Agnarsson8,9, Munaza Ahmed10, Kristiina Aittomäki11, Elisa Alducci7, Irene L Andrulis12,13, Adalgeir Arason8,14, Norbert Arnold15, Grazia Artioli16, Brita Arver17, Bernd Auber18, Jacopo Azzollini19, Judith Balmaña20, Rosa B Barkardottir8,14, Daniel R Barnes5, Alicia Barroso21, Daniel Barrowdale5, Muriel Belotti22, Javier Benitez23,24, Birgitte Bertelsen25, Marinus J Blok26, Istvan Bodrogi27, Valérie Bonadona28, Bernardo Bonanni29, Davide Bondavalli29, Susanne E Boonen30, Julika Borde31,32,33, Ake Borg34, Angela R Bradbury35, Angela Brady36, Carole Brewer37, Joan Brunet38, Bruno Buecher22, Saundra S Buys39, Santiago Cabezas-Camarero40, Trinidad Caldés41, Almuth Caliebe42, Maria A Caligo43, Mariarosaria Calvello29, Ian G Campbell44,45, Ileana Carnevali46, Estela Carrasco20, Tsun L Chan47,48, Annie T W Chu47, Wendy K Chung49, Kathleen B M Claes50, Gemo Study Collaborators22, Embrace Collaborators5, Jackie Cook51, Laura Cortesi52, Fergus J Couch53, Mary B Daly54, Giuseppe Damante55, Esther Darder38, Rosemarie Davidson56, Miguel de la Hoya41, Lara Della Puppa57, Joe Dennis5, Orland Díez58, Yuan Chun Ding59, Nina Ditsch60, Susan M Domchek35, Alan Donaldson61, Bernd Dworniczak62, Douglas F Easton5,63, Diana M Eccles64, Rosalind A Eeles65, Hans Ehrencrona66, Bent Ejlertsen67, Christoph Engel68,69, D Gareth Evans70,71, Laurence Faivre72, Ulrike Faust73, Lídia Feliubadaló74, Lenka Foretova75, Florentia Fostira76, George Fountzilas77, Debra Frost5, Vanesa García-Barberán41, Pilar Garre41, Marion Gauthier-Villars22, Lajos Géczi27, Andrea Gehrig78, Anne-Marie Gerdes79, Paul Gesta80, Giuseppe Giannini81, Gord Glendon12, Andrew K Godwin82, David E Goldgar83, Mark H Greene84, Angelica M Gutierrez-Barrera85, Eric Hahnen32,33, Ute Hamann86, Jan Hauke31,32,33, Natalie Herold31,32,33, Frans B L Hogervorst87, Ellen Honisch88, John L Hopper89, Peter J Hulick90,91, KConFab Investigators44,45, Hebon Investigators92, Louise Izatt93, Agnes Jager94, Paul James45,95, Ramunas Janavicius96, Uffe Birk Jensen97, Thomas Dyrso Jensen98, Oskar Th Johannsson99, Esther M John100, Vijai Joseph101, Eunyoung Kang102, Karin Kast103, Johanna I Kiiski104, Sung-Won Kim105, Zisun Kim106, Kwang-Pil Ko107, Irene Konstantopoulou76, Gero Kramer108, Lotte Krogh109, Torben A Kruse109, Ava Kwong47,110,111, Mirjam Larsen31,32,33, Christine Lasset28, Charlotte Lautrup112, Conxi Lazaro74, Jihyoun Lee113, Jong Won Lee114, Min Hyuk Lee113, Johannes Lemke115, Fabienne Lesueur22,116,117,118, Annelie Liljegren17, Annika Lindblom119,120, Patricia Llovet41, Adria Lopez-Fernández20, Irene Lopez-Perolio41, Victor Lorca41, Jennifer T Loud84, Edmond S K Ma47,48, Phuong L Mai121, Siranoush Manoukian19, Veronique Mari122, Lynn Martin123, Laura Matricardi7, Noura Mebirouk22,116,117,118, Veronica Medici52, Hanne E J Meijers-Heijboer124, Alfons Meindl60, Arjen R Mensenkamp125, Clare Miller126, Denise Molina Gomes127, Marco Montagna7, Thea M Mooij128, Lidia Moserle7, Emmanuelle Mouret-Fourme22, Anna Marie Mulligan129,130, Katherine L Nathanson35, Marie Navratilova75, Heli Nevanlinna104, Dieter Niederacher89, Finn C Cilius Nielsen25, Liene Nikitina-Zake131, Kenneth Offit102,132, Edith Olah133, Olufunmilayo I Olopade134, Kai-Ren Ong135, Ana Osorio23,24, Claus-Eric Ott136, Domenico Palli137, Sue K Park138,139,140, Michael T Parsons141, Inge Sokilde Pedersen142, Bernard Peissel19, Ana Peixoto143, Pedro Pérez-Segura40, Paolo Peterlongo144, Annabeth Høgh Petersen98, Mary E Porteous145, Miguel Angel Pujana146, Paolo Radice147, Juliane Ramser148, Johanna Rantala149, Muhammad U Rashid86,150, Kerstin Rhiem31,32,33, Piera Rizzolo81, Mark E Robson132, Matti A Rookus128, Caroline M Rossing25, Kathryn J Ruddy151, Catarina Santos143, Claire Saule22, Rosa Scarpitta152, Rita K Schmutzler32,33, Hélène Schuster153, Leigha Senter154, Caroline M Seynaeve94, Payal D Shah35, Priyanka Sharma155, Vivian Y Shin110, Valentina Silvestri81, Jacques Simard156, Christian F Singer157, Anne-Bine Skytte98, Katie Snape158, Angela R Solano159, Penny Soucy155, Melissa C Southey160,161, Amanda B Spurdle141, Linda Steele59, Doris Steinemann162, Dominique Stoppa-Lyonnet22,163,164, Agostina Stradella165, Lone Sunde97, Christian Sutter166, Yen Y Tan167, Manuel R Teixeira143,168, Soo Hwang Teo169,170, Mads Thomassen109, Maria Grazia Tibiletti46, Marc Tischkowitz171,172, Silvia Tognazzo7, Amanda E Toland173, Stefania Tommasi174, Diana Torres86,175, Angela Toss52, Alison H Trainer95, Nadine Tung176, Christi J van Asperen177, Frederieke H van der Baan128, Lizet E van der Kolk87, Rob B van der Luijt178, Liselotte P van Hest179, Liliana Varesco180, Raymonda Varon-Mateeva136, Alessandra Viel57, Jeroen Vierstraete50, Roberta Villa19, Anna von Wachenfeldt17, Philipp Wagner181, Shan Wang-Gohrke182, Barbara Wappenschmidt32,33, Jeffrey N Weitzel183, Greet Wieme50, Siddhartha Yadav151, Drakoulis Yannoukakos76, Sook-Yee Yoon184, Cristina Zanzottera19, Kristin K Zorn121, Anthony V D'Amico1, Matthew L Freedman4, Mark M Pomerantz4, Georgia Chenevix-Trench141, Antonis C Antoniou5, Susan L Neuhausen59, Laura Ottini81, Henriette Roed Nielsen109, Timothy R Rebbeck185,4.
Abstract
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual. ©2019 American Association for Cancer Research.Entities:
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Year: 2019 PMID： 31723001 PMCID： PMC7553241 DOI： 10.1158/0008-5472.CAN-19-1840
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 13.312