Mary Inziani1, Ferdinard Adungo2, Janet Awando3, Richelle Kihoro3, Shingo Inoue4, Kouichi Morita5, Elizabeth Obimbo6, Francis Onyango6, Matilu Mwau2. 1. Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya. Electronic address: mmuyeku@kemri.org. 2. Centre for Infectious and Parasitic Diseases Control Research (CIPDCR), Kenya Medical Research Institute, Busia, Kenya. 3. Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya. 4. Nagasaki University Africa Research Station, Nairobi, Kenya. 5. Nagasaki University Institute of Tropical Medicine, Nagasaki, Japan. 6. Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Abstract
BACKGROUND: Arboviruses often cause widespread morbidity in children in endemic regions. Data on the burden of arboviruses in Kenyan children are limited. OBJECTIVES: This study was performed to determine the seroprevalence of yellow fever (YFV), dengue (DENV), West Nile (WNV), and chikungunya (CHIKV) viruses among children 1-12 years of age at two health facilities in Teso South Sub-County in Western Kenya. METHODS: In a hospital-based cross-sectional survey, a questionnaire was used to collect socio-demographic information. Serum drawn from the children was tested for IgA/IgM/IgG serocomplex antibodies to selected arboviruses using indirect ELISA and plaque reduction neutralization tests. RESULTS: A total of 182 (27.7%) of the 656 participants tested were positive for any arbovirus antibody. Of these, 4.4% (29/656) tested positive for YFV, 9.6% (62/649) for WNV, 5.6% (36/649) for CHIKV, 1.4% (5/368) for DENV1, 9% (59/656) for DENV2, and 19.7% (40/203) for DENV3. Neutralizing antibodies to CHIKV were found in 77.8% (42/54) of participants, to YFV in 15.8% (3/19), to DENV2 in 58% (29/50), and to WNV in 8% (1/55). Sex, age, urban residence, schooling, and lack of vaccination were associated with arbovirus exposure. CONCLUSIONS: This study confirmed that children under 12 years of age in Teso South Sub-County are exposed to ongoing arbovirus infections early in life.
BACKGROUND: Arboviruses often cause widespread morbidity in children in endemic regions. Data on the burden of arboviruses in Kenyan children are limited. OBJECTIVES: This study was performed to determine the seroprevalence of yellow fever (YFV), dengue (DENV), West Nile (WNV), and chikungunya (CHIKV) viruses among children 1-12 years of age at two health facilities in Teso South Sub-County in Western Kenya. METHODS: In a hospital-based cross-sectional survey, a questionnaire was used to collect socio-demographic information. Serum drawn from the children was tested for IgA/IgM/IgG serocomplex antibodies to selected arboviruses using indirect ELISA and plaque reduction neutralization tests. RESULTS: A total of 182 (27.7%) of the 656 participants tested were positive for any arbovirus antibody. Of these, 4.4% (29/656) tested positive for YFV, 9.6% (62/649) for WNV, 5.6% (36/649) for CHIKV, 1.4% (5/368) for DENV1, 9% (59/656) for DENV2, and 19.7% (40/203) for DENV3. Neutralizing antibodies to CHIKV were found in 77.8% (42/54) of participants, to YFV in 15.8% (3/19), to DENV2 in 58% (29/50), and to WNV in 8% (1/55). Sex, age, urban residence, schooling, and lack of vaccination were associated with arbovirus exposure. CONCLUSIONS: This study confirmed that children under 12 years of age in Teso South Sub-County are exposed to ongoing arbovirus infections early in life.
Authors: Tatenda Chiuya; Jandouwe Villinger; Laura C Falzon; Lorren Alumasa; Fredrick Amanya; Armanda D S Bastos; Eric M Fèvre; Daniel K Masiga Journal: Malar J Date: 2022-09-17 Impact factor: 3.469
Authors: Tatenda Chiuya; Daniel K Masiga; Laura C Falzon; Armanda D S Bastos; Eric M Fèvre; Jandouwe Villinger Journal: Transbound Emerg Dis Date: 2020-12-05 Impact factor: 5.005