Aravind Reddy Kuchkuntla1, Meera Shah2, Saketh Velapati2, Victoria M Gershuni3, Tamim Rajjo1, Sanjeev Nanda4, Ryan T Hurt2,4,5, Manpreet S Mundi6. 1. Department of Family Medicine, Mayo Clinic, Rochester, MN, USA. 2. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. 3. Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. 4. Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA. 5. Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA. 6. Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Mundi.manpreet@mayo.edu.
Abstract
PURPOSE OF REVIEW: Obesity and its related comorbidities make up a large part of healthcare expenditures. Despite a wide array of options for treatment of obesity, rates of sustained weight loss continue to be low, leading patients to seek alternative treatment options. Although the first medically utilized ketogenic diet was described nearly 100 years ago, it has made a resurgence as a treatment option for obesity. Despite increased popularity in the lay public and increased use of ketogenic dietary strategies for metabolic therapy, we are still beginning to unravel the metabolic impact of long-term dietary ketosis. RECENT FINDINGS: There are a number of recent trials that have highlighted the short- and long-term benefits of ketogenic diet on weight, glycemic control, and other endocrine functions including reproductive hormones. This review is a summary of available data on the effectiveness and durability of the ketogenic diet when compared to conventional interventions. Ketogenic dietary strategies may play a role in short-term improvement of important metabolic parameters with potential for long-term benefit. However, response may vary due to inter-individual ability to maintain long-term carbohydrate restriction.
PURPOSE OF REVIEW: Obesity and its related comorbidities make up a large part of healthcare expenditures. Despite a wide array of options for treatment of obesity, rates of sustained weight loss continue to be low, leading patients to seek alternative treatment options. Although the first medically utilized ketogenic diet was described nearly 100 years ago, it has made a resurgence as a treatment option for obesity. Despite increased popularity in the lay public and increased use of ketogenic dietary strategies for metabolic therapy, we are still beginning to unravel the metabolic impact of long-term dietary ketosis. RECENT FINDINGS: There are a number of recent trials that have highlighted the short- and long-term benefits of ketogenic diet on weight, glycemic control, and other endocrine functions including reproductive hormones. This review is a summary of available data on the effectiveness and durability of the ketogenic diet when compared to conventional interventions. Ketogenic dietary strategies may play a role in short-term improvement of important metabolic parameters with potential for long-term benefit. However, response may vary due to inter-individual ability to maintain long-term carbohydrate restriction.
Entities:
Keywords:
Diabetes; Ketogenic diet; Obesity; Weight loss
Authors: Saketh R Velapati; Meera Shah; Aravind R Kuchkuntla; Barham Abu-Dayyeh; Karen Grothe; Ryan T Hurt; Manpreet S Mundi Journal: Curr Nutr Rep Date: 2018-12
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