Literature DB >> 17167474

Inflammation and metabolic disorders.

Gökhan S Hotamisligil1.   

Abstract

Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare.

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Mesh：

Year:  2006        PMID： 17167474     DOI： 10.1038/nature05485

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  2000 in total

1.  Estrogen receptor-α signaling maintains immunometabolic function in males and is obligatory for exercise-induced amelioration of nonalcoholic fatty liver.

Authors:  Nathan C Winn; Thomas J Jurrissen; Zachary I Grunewald; Rory P Cunningham; Makenzie L Woodford; Jill A Kanaley; Dennis B Lubahn; Camila Manrique-Acevedo; R Scott Rector; Victoria J Vieira-Potter; Jaume Padilla
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-12-04       Impact factor: 4.310

Review 2.  T Cell Populations and Functions Are Altered in Human Obesity and Type 2 Diabetes.

Authors:  Sothea Touch; Karine Clément; Sébastien André
Journal:  Curr Diab Rep       Date:  2017-09       Impact factor: 4.810

Review 3.  cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance.

Authors:  Guadalupe Sabio; Roger J Davis
Journal:  Trends Biochem Sci       Date:  2010-05-07       Impact factor: 13.807

4.  A novel dual PPAR-γ agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.

Authors:  Md Abdul Hye Khan; Lauren Kolb; Melissa Skibba; Markus Hartmann; René Blöcher; Ewgenij Proschak; John D Imig
Journal:  Diabetologia       Date:  2018-07-21       Impact factor: 10.122

5.  Metabolic Changes in Androgen-Deprived Nondiabetic Men With Prostate Cancer Are Not Mediated by Cytokines or aP2.

Authors:  Thiago Gagliano-Jucá; M Furkan Burak; Karol M Pencina; Zhuoying Li; Robert R Edwards; Thomas G Travison; Shehzad Basaria
Journal:  J Clin Endocrinol Metab       Date:  2018-10-01       Impact factor: 5.958

Review 6.  Bioenergetic regulation of microglia.

Authors:  Soumitra Ghosh; Erika Castillo; Elma S Frias; Raymond A Swanson
Journal:  Glia       Date:  2017-12-08       Impact factor: 7.452

7.  Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity.

Authors:  Irina Mikhailovna Bochkis; Soona Shin; Klaus Hermann Kaestner
Journal:  Mol Metab       Date:  2013-08-24       Impact factor: 7.422

Review 8.  Neuroinflammatory basis of metabolic syndrome.

Authors:  Sudarshana Purkayastha; Dongsheng Cai
Journal:  Mol Metab       Date:  2013-10-05       Impact factor: 7.422

9.  Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling.

Authors:  Hye-Ji Noh; Chu-Sook Kim; Ji-Hye Kang; Jun-Young Park; Suck-Young Choe; Soon-Myoung Hong; Hoon Yoo; Taesun Park; Rina Yu
Journal:  J Med Food       Date:  2013-12-10       Impact factor: 2.786

10.  Gut microbiome composition is linked to whole grain-induced immunological improvements.

Authors:  Inés Martínez; James M Lattimer; Kelcie L Hubach; Jennifer A Case; Junyi Yang; Casey G Weber; Julie A Louk; Devin J Rose; Gayaneh Kyureghian; Daniel A Peterson; Mark D Haub; Jens Walter
Journal:  ISME J       Date:  2012-10-04       Impact factor: 10.302
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